Objective: Fluid administration in combination with the increase in vasopermeability induced
by critical illness often results in significant fluid overload in critically ill patients. Recent …

In patients with septic shock, the administration of fluids during initial hemodynamic
resuscitation remains a major therapeutic challenge. We are faced with many open …

Background Intravenous fluids are recommended for the treatment of patients who are in
septic shock, but higher fluid volumes have been associated with harm in patients who are …

Background Multi-organ dysfunction in critical illness is common and frequently involves the
lungs and kidneys, often requiring organ support such as invasive mechanical ventilation …

Purpose Current reports on acute kidney injury (AKI) in the intensive care unit (ICU) show
wide variation in occurrence rate and are limited by study biases such as use of incomplete …

Continuous renal replacement therapy (CRRT) is commonly used to provide renal support
for critically ill patients with acute kidney injury, particularly patients who are …

Abstract Background Fluid challenges (FCs) are one of the most commonly used therapies
in critically ill patients and represent the cornerstone of hemodynamic management in …

Background: Sepsis is associated with generalised endothelial injury and capillary leak and
has traditionally been treated with large volume fluid resuscitation. Some patients with …

Importance After initial resuscitation, critically ill children may accumulate fluid and develop
fluid overload. Accruing evidence suggests that fluid overload contributes to greater …

Purpose We assessed the effects of a protocol restricting resuscitation fluid vs. a standard
care protocol after initial resuscitation in intensive care unit (ICU) patients with septic shock …