Many diseases are caused by insufficient expression of mutated genes and would benefit
from increased expression of the corresponding protein. However, in drug development, it …

Gliomas are the most lethal primary brain tumors in adults. These highly invasive tumors
have poor 5-year survival for patients. Gliomas are principally characterized by rapid …

Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer.
MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the …

Genetic alterations drive tumor onset and progression. However, the cross‑talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …

Cancer metastasis is the primary cause of cancer-related deaths. The seeding of primary
tumours at a secondary site is a highly inefficient process requiring substantial alterations in …

Aims The effect of surface-modification of Tamoxifen (Tam)-loaded-niosomes on drug
cytotoxicity and bio-distribution, via functionalization with chitosan and/or PEGylation, was …

As small non-coding RNAs, MicroRNAs (miRNAs) bind to the 3′ untranslated region (3′-
UTR) of mRNA targets to control gene transcription and translation. The gene of miR-330 …

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by persistent
hyperglycemia and is associated with serious complications. The risk factors for T2DM …

MicroRNAs have been projected as promising tools for diagnostic and prognostic purposes
in cancer. More recently, they have been highlighted as RNA therapeutic targets for cancer …