Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide, accounting
for 10% to 15% of all deaths. Although most arrhythmias are due to acquired heart disease …

Cardiovascular diseases are the leading cause of mortality and morbidity worldwide and
account for more than 17.9 million deaths (World Health Organization report). Hypertension …

Preclinical large animal models of heart failure (HF) play a critical and expanding role in
translating basic science findings to the development and clinical approval of novel …

Background Cardiac dysfunction developing in response to chronic pressure overload is
associated with apoptotic cell death and myocardial vessel rarefaction. We examined …

Background Increasing evidence suggests a critical role for mitochondrial aldehyde
dehydrogenase 2 (ALDH 2) in protection against cardiac injuries; however, the downstream …

Traumatic brain injury (TBI) causes progressive dysfunction that induces biochemical and
metabolic changes that lead to cell death. Nevertheless, there is no definitive FDA-approved …

In this study, the potential influence of resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) in
signal transducer and activator of transcription 3 (STAT3) signaling of medulloblastoma cells …

The protective effect of hydrogen sulfide (H 2 S) against myocardial ischemia/reperfusion
(IR) injury via anti-apoptotic signaling is well established, but the underlying mechanism …

Mechanistic target of rapamycin (mTOR) is a central regulator of cell growth, proliferation,
survival and metabolism, as part of mTOR complex 1 (mTORC1) and mTORC2. While partial …

Cardiomyocyte apoptosis is a well-established contributor to irreversible injury following
myocardial infarction (MI). Increased cardiomyocyte apoptosis is associated also with aging …