Whole-body health relies on complex inter-organ signalling networks that enable organisms
to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine …

In multicellular organisms, endocrine factors such as hormones and cytokines regulate
development and homoeostasis through communication between different organs. For …

Obesity imposes a global health threat and calls for safe and effective therapeutic options.
Here, we found that protein-rich diet significantly reduced body fat storage in fruit flies, which …

Nonalcoholic fatty liver disease (NAFLD) is a global health concern with no approved drugs.
High-protein dietary intervention is currently the most effective treatment. However, its …

Micro-and nanoplastics (MNPLs) are intentionally produced for commercial uses (primary
MNPLs) or are formed from environmentally aged plastics (secondary MNPLs). Independent …

The natural compound plumbagin has a wide range of pharmacological and potential
therapeutic activities, although its role in neuroretina degeneration is unknown. Here we …

Nutrient availability is a major selective force in the evolution of metazoa, and thus plasticity
in tissue function and morphology is shaped by adaptive responses to nutrient changes …

Precise coupling between cellular physiology and metabolism is emerging as a vital
relationship underpinning tissue health and longevity. Nevertheless, functional-metabolic …

Conditional gene regulation in Drosophila through binary expression systems like the LexA-
LexAop system provides a superb tool for investigating gene and tissue function. To …

Metazoans establish mutually beneficial interactions with their resident microorganisms.
However, our understanding of the microbial cues contributing to host physiology remains …