Simple Summary Immunotherapy has made a breakthrough in the treatment of patients with
recurrent and/or metastatic head and neck squamous cell carcinoma in the second line …

Immunotherapy combinations are being investigated to expand the benefit of immune
checkpoint blockade across many cancer types. Radiation combinations, in particular using …

Recent advancements in the development of immunotherapies have raised the hope for
patients with locally-advanced HNSCC (LA-HNSCC) to achieve improved oncologic …

BACKGROUND The outcomes of patients diagnosed with head and neck squamous cell
carcinoma (HNSCC) who are not candidates for local salvage therapy and of those …

Since its first clinical application, 120 years ago, radiotherapy evolved into a major anti-
cancer treatment modality, offering high cure rates in many human malignancies. During the …

Radiotherapy and immunotherapy benefit subsets of patients with metastatic cancer. Here,
we review selected laboratory and clinical studies investigating the utility of combining …

The treatment landscape of locally advanced HPV-oropharyngeal squamous cell carcinoma
(OPSCC) is undergoing transformation. This is because the high cures rates observed in …

Radiation therapy is traditionally used for the local control of tumour growth, but recent
studies suggest that radiation therapy can have immunomodulatory properties that can be …

Purpose Immunotherapy with checkpoint inhibitors has an enormous potential in therapy of
metastatic cancers. Immunotherapy is generally combined with local treatments, such as …

Ionizing radiation can have a wide range of impacts on tumor–immune interactions, which
are being studied with the greatest interest and at an accelerating pace by the medical …