Staphylococcus aureus is a facultative, Gram-positive coccus well known for its disease-
causing capabilities. In particular, methicillin and vancomycin resistant strains of S. aureus …

With the amount of genetic information available, a lot of attention has focused on systems
biology, in particular biomolecular interactions. Considering the huge number of such …

Superantigens are a class of highly potent immuno-stimulatory molecules produced by
Staphylococcus aureus and Streptococcus pyogenes. These toxins possess the unique …

AT cell antigen receptor (TCR) transmembrane sequence derived peptide (CP) has been
shown to inhibit T cell activation both in vitro and in vivo at the membrane level of the …

Staphylococcal enterotoxin A (SEA) is a potent stimulator of CD4+ and CD8+ T cells, the
immunotoxic action of which remains unclear. We investigated the in vitro effects of SEA on …

Bacterial superantigens are potent T-cell stimulatory protein molecules produced by
Staphylococcus aureus and Streptococcus pyogenes 1. Their function in the microbe …

The superantigen SEA causes non-specific hyperactivation of T and B cells at low
concentrations. Studies of mutants or soluble proteins suggest SEA is bivalent for its ligand …

Toxic shock syndrome (TSS), a life-threatening illness, is caused by excessively high
concentrations of proinflammatory cytokines released after superantigen stimulation of T-cell …

In antigen presenting cells, MHC class II molecules bind peptide fragments and present
them to CD4+" helper" T cells. The antigen processing pathway in these cells involves a …

Superantigens trigger the polyclonal activation of human T cells. We exploited this property
to gain insight into the mechanisms governing CD4 T cell expansion and to study the …