Atomic-resolution structural studies of membrane-associated proteins and peptides in a
membrane environment are important to fully understand their biological function and the …

Compared to soluble protein counterparts, the understanding of membrane protein stability,
solvent interactions, and function are not as well understood. Recent advancements in …

Although polymer-based lipid nanodiscs are increasingly used in the structural studies of
membrane proteins, the charge of the belt-forming polymer is a major limitation for functional …

The nanodisc technology is increasingly used for structural studies on membrane proteins
and drug delivery. The development of synthetic polymer nanodiscs and the recent …

Cell membranes represent a complex and variable medium in time and space of lipids and
proteins. Their physico-chemical properties are determined by lipid components which can …

Membrane proteins represent the majority of clinical drug targets and are actively involved in
a range of cellular processes. However, the complexity of membrane mimetics for …

G protein-coupled receptors (GPCRs) are involved in a multitude of cellular signaling
cascades and consequently are a prominent target for pharmaceutical drugs. In the past …

Highlights•This review summarizes the immobilization methods of receptor
chromatography.•The applications of receptor chromatography are discussed.•Future …

We monitored the effect on function of the G-protein-coupled receptor (GPCR) rhodopsin
from small, stepwise changes in bilayer thickness induced by cholesterol. Over a range of …

High-resolution structural NMR analyses of membrane proteins are challenging due to their
large size, resulting in broad resonances and strong signal overlap. Among the isotope …