The immunoregulatory landscape of human tuberculosis granulomas
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in
infected tissues, the architecture and composition of which are thought to affect disease …
infected tissues, the architecture and composition of which are thought to affect disease …
A survey of gene expression meta-analysis: methods and applications
D Toro-Domínguez, JA Villatoro-Garciá… - Briefings in …, 2021 - academic.oup.com
The increasing use of high-throughput gene expression quantification technologies over the
last two decades and the fact that most of the published studies are stored in public …
last two decades and the fact that most of the published studies are stored in public …
Advanced model systems and tools for basic and translational human immunology
There are fundamental differences between humans and the animals we typically use to
study the immune system. We have learned much from genetically manipulated and inbred …
study the immune system. We have learned much from genetically manipulated and inbred …
Beyond experiments
It is often claimed that only experiments can support strong causal inferences and therefore
they should be privileged in the behavioral sciences. We disagree. Overvaluing experiments …
they should be privileged in the behavioral sciences. We disagree. Overvaluing experiments …
Increased monocyte count as a cellular biomarker for poor outcomes in fibrotic diseases: a retrospective, multicentre cohort study
Background There is an urgent need for biomarkers to better stratify patients with idiopathic
pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical …
pulmonary fibrosis by risk for lung transplantation allocation who have the same clinical …
Noninvasive blood tests for fetal development predict gestational age and preterm delivery
TTM Ngo, MN Moufarrej, MLH Rasmussen… - Science, 2018 - science.org
Noninvasive blood tests that provide information about fetal development and gestational
age could potentially improve prenatal care. Ultrasound, the current gold standard, is not …
age could potentially improve prenatal care. Ultrasound, the current gold standard, is not …
A community approach to mortality prediction in sepsis via gene expression analysis
Improved risk stratification and prognosis prediction in sepsis is a critical unmet need.
Clinical severity scores and available assays such as blood lactate reflect global illness …
Clinical severity scores and available assays such as blood lactate reflect global illness …
Leveraging heterogeneity across multiple datasets increases cell-mixture deconvolution accuracy and reduces biological and technical biases
In silico quantification of cell proportions from mixed-cell transcriptomics data
(deconvolution) requires a reference expression matrix, called basis matrix. We hypothesize …
(deconvolution) requires a reference expression matrix, called basis matrix. We hypothesize …
Interpretation of biological experiments changes with evolution of the Gene Ontology and its annotations
Gene Ontology (GO) enrichment analysis is ubiquitously used for interpreting high
throughput molecular data and generating hypotheses about underlying biological …
throughput molecular data and generating hypotheses about underlying biological …
Gene annotation bias impedes biomedical research
We found tremendous inequality across gene and protein annotation resources. We
observed that this bias leads biomedical researchers to focus on richly annotated genes …
observed that this bias leads biomedical researchers to focus on richly annotated genes …