PTEN is one of the most frequently inactivated tumor suppressor genes in cancer. Loss or
variation in PTEN gene/protein levels is commonly observed in a broad spectrum of human …

Approximately 15% of cancers are attributable to the inflammatory process, and growing
evidence supports an association between oral squamous cell carcinoma (OSCC) and …

The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

AKR1C3 is an enzyme belonging to the aldo-ketoreductase family, the members of which
catalyze redox transformations involved in biosynthesis, intermediary metabolism, and …

Hepatocellular carcinoma (HCC), the main pathological type of liver cancer, is linked to risk
factors such as viral hepatitis, alcohol intake and non‐alcoholic fatty liver disease (NAFLD) …

Liver cancer is a malignancy developed from underlying liver disease that encompasses
liver injury and metabolic disorders. The progression from these underlying liver disease to …

Abstract Changes in reactive oxygen species (ROS) levels affect many aspects of cell
behavior. During carcinogenesis, moderate ROS production modifies gene expression to …

Several studies suggest that glial scars pose as physical and chemical barriers that limit
neurite regeneration after spinal cord injury (SCI). Evidences suggest that the activation of …

Chemotherapy is a major therapeutic option for cancer patients. However, its effectiveness is
challenged by chemodrugs' intrinsic pathological interactions with residual cancer cells …

Peroxisome proliferator‐activated receptors (PPARs) are transcription factors belonging to
the nuclear receptor family. There are three subtypes of PPARs, including PPAR‐α, PPAR …