The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters
family found in humans. These proteins actively transport endogenous and exogenous …

During the past two decades the first sequencing of the human genome was performed
showing its high degree of inter-individual differentiation, as a result of large international …

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important
mechanisms responsible for the development of multidrug resistance (MDR). Selonsertib, a …

ATP-binding cassette (ABC) transporters mediate multidrug resistance in cancer. In contrast
to DNA single nucleotide polymorphisms in normal tissues, the role of mutations in tumors is …

While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an
objective response rate around 20%, the administration of combinations of irinotecan with 5 …

Colorectal cancer (CRC) represents one of the most common malignancies and is major
cause of cancer-related deaths worldwide. A great improvement in response rate and …

Recent advances in next generation sequencing reinforce the potential for DNA sequence
markers to guide esophageal cancer management. We report the first systematic review and …

Overexpression of ABC transporters in cancer cells is an underlying mechanism of multidrug
resistance (MDR), leading to insensitive response to chemotherapeutic strategies. Thus …

Abstract Since over 50 years, 5-fluorouracil (5-FU) is in use as backbone of chemotherapy
treatment regimens for a wide range of cancers including colon, breast, and head and neck …

Chemotherapy regimen containing oxaliplatin is often the first‐line treatment for patient with
advanced colorectal cancer. Oxaliplatin binds to DNA, leading to the formation of crosslinks …