“Omics”-informed drug and biomarker discovery: opportunities, challenges and future perspectives

H Matthews, J Hanison, N Nirmalan - Proteomes, 2016 - mdpi.com
The pharmaceutical industry faces unsustainable program failure despite significant
increases in investment. Dwindling discovery pipelines, rapidly expanding R&D budgets …

Unveiling the potential of proteomic and genetic signatures for precision therapeutics in lung cancer management

S Srivastava, N Jayaswal, S Kumar, PK Sharma… - Cellular …, 2024 - Elsevier
Lung cancer's enduring global significance necessitates ongoing advancements in
diagnostics and therapeutics. Recent spotlight on proteomic and genetic biomarker research …

[HTML][HTML] Proteomics applications in health: biomarker and drug discovery and food industry

N Amiri-Dashatan, M Koushki… - Iranian journal of …, 2018 - ncbi.nlm.nih.gov
Advancing in genome sequencing has greatly propelled the understanding of the living
world; however, it is insufficient for full description of a biological system. Focusing on …

Comparative proteomic analysis of esophageal squamous cell carcinoma

Y Qi, JF Chiu, L Wang, DLW Kwong, QY He - Proteomics, 2005 - Wiley Online Library
Ranking as the fourth commonest cancer, esophageal squamous cell carcinoma (ESCC)
represents one of the leading causes of cancer death in China. One of the main reasons for …

Biomarkers in spinal cord injury: prognostic insights and future potentials

AA Albayar, A Roche, P Swiatkowski, S Antar… - Frontiers in …, 2019 - frontiersin.org
Spinal Cord Injury (SCI) is a major challenge in Neurotrauma research. Complex
pathophysiological processes take place immediately after the injury and later on as the …

Evaluation of In vitro Assays for Assessing the Toxicity of Cigarette Smoke and Smokeless Tobacco

MD Johnson, J Schilz, MV Djordjevic, JR Rice… - … , biomarkers & prevention, 2009 - AACR
Background: In vitro toxicology studies of tobacco and tobacco smoke have been used to
understand why tobacco use causes cancer and to assess the toxicologic impact of tobacco …

Statistical analysis of proteomics data: a review on feature selection

M Lualdi, M Fasano - Journal of proteomics, 2019 - Elsevier
The spread of “-omics” strategies has strongly changed the way of thinking about the
scientific method. Indeed, managing huge amounts of data imposes the replacement of the …

[HTML][HTML] Proteomics: Concepts and applications in human medicine

S Al-Amrani, Z Al-Jabri, A Al-Zaabi… - World journal of …, 2021 - ncbi.nlm.nih.gov
Proteomics is the complete evaluation of the function and structure of proteins to understand
an organism's nature. Mass spectrometry is an essential tool that is used for profiling …

Assessing amide proton transfer (APT) MRI contrast origins in 9 L gliosarcoma in the rat brain using proteomic analysis

K Yan, Z Fu, C Yang, K Zhang, S Jiang, DH Lee… - Molecular imaging and …, 2015 - Springer
Purpose To investigate the biochemical origin of the amide photon transfer (APT)-weighted
hyperintensity in brain tumors. Procedures Seven 9 L gliosarcoma-bearing rats were imaged …

Identification of tumor‐associated proteins in oral tongue squamous cell carcinoma by proteomics

QY He, J Chen, HF Kung, APW Yuen, JF Chiu - Proteomics, 2004 - Wiley Online Library
Oral tongue carcinoma is an aggressive tumor that particularly affects chronic smokers,
drinkers and betel squid chewers. Patients often present symptoms at a late stage, and there …