Abstract Characterization of the cellular participants in tissue immune responses is crucial to
understanding infection, cancer, autoimmunity, allergy, graft rejection and other …

Sphingosine 1-phosphate (S1P) is a membrane-derived lysophospholipid that acts primarily
as an extracellular signaling molecule. Signals initiated by S1P are transduced by five G …

INTRODUCTION Secretory immunoglobulin A (IgA) is made by intestinal plasma cells and
has roles both in protection from gut pathogens and in maintaining homeostasis of intestinal …

Proteolysis is an irreversible physiological process that can result in the termination or
activation of protein function. Many transmembrane proteins that are involved in the cellular …

Sphingosine‐1‐phosphate (S1P) is a bioactive sphingolipid metabolite involved in many
critical cell processes. It is produced by the phosphorylation of sphingosine by sphingosine …

The microanatomical structure of the spleen has been primarily described in mice and rats.
This leads to terminological problems with respect to humans and their species‐specific …

Marginal zone (MZ) B cells comprise a subset of innate-like B cells found predominantly in
the spleen, but also in lymph nodes and blood. Their principal functions are participation in …

Germinal centers (GC) are the main sites where antigen‐activated B‐cell clones expand and
undergo immunoglobulin gene hypermutation and selection. Iterations of this process will …

The most aggressive B cell lymphomas frequently manifest extranodal distribution and carry
somatic mutations in the poorly characterized gene TBL1XR1. Here, we show that TBL1XR1 …

Intravital microscopy has become increasingly popular over the past few decades because it
provides high-resolution and real-time information about complex biological processes …