Abstract Background Intestinal Peyer's patches (PPs) form unique niches for bacteria-
immune cell interactions that direct host immunity and shape the microbiome. Here we …

Red blood cell (RBC) transfusions can result in alloimmunization toward RBC alloantigens
that can increase the probability of complications following subsequent transfusion. An …

CD8 effector T cells with a CD127 hi KLRG1− phenotype are considered precursors to the
long-lived memory pool, whereas KLRG1+ CD127 low cells are viewed as short-lived …

The tumor-derived factors involved in the expansion and accumulation of myeloid-derived
suppressor cells (MDSCs) in metastatic dissemination of colorectal cancer (CRC) to the liver …

Antibodies, forming immune complexes with their specific antigen, can cause complete
suppression or several 100-fold enhancement of the antibody response. Immune complexes …

Immune responses highly depend on the effective trafficking of immune cells into and within
secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge …

B-cell development is characterized by a number of tightly regulated selection processes.
Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation …

Follicular B (FoB) and marginal zone B (MZB) cells are functionally and spatially distinct
mature B cell populations in the spleen, originating from a Notch2-dependent fate decision …

Intravital microscopic imaging can uncover fundamental aspects of immune cell behavior in
real time in both healthy and pathological states. Here, we discuss approaches for single …

Lymphocyte homeostasis and immune surveillance require that T and B cells continuously
recirculate between secondary lymphoid organs. Here, we used intravital microscopy to …