Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …

Co-amorphous drug delivery systems (CAMS) are characterized by the combination of two
or more (initially crystalline) low molecular weight components that form a homogeneous …

Solid dispersion is the preferred technology to prepare efficacious forms of BCS class-II/IV
APIs. To prepare solid dispersions, there exist a wide variety of polymeric carriers with …

Amino acids are natural compounds that can be safely used in pharmaceutical applications.
Considering the great interest in the amino acids used in the pharmaceutical industry, this …

The preparation of amorphous solid dispersion (ASD) formulations is a promising strategy to
improve the bioavailability of an active pharmaceutical ingredient (API). By dissolving the …

In this study, a comparison of different methods to predict drug–polymer solubility was
carried out on binary systems consisting of five model drugs (paracetamol, chloramphenicol …

Introduction: Amorphous solid dispersions are considered as one of the most powerful
strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical …

We have previously developed a fast screening method on the ability of twenty amino acids
(AA) to form co-amorphous formulations with six drugs upon ball milling. In this work, the …

Amorphous solid dispersions (ASDs) are probably the most common and important
supersaturating drug delivery systems for the formulation of poorly water-soluble …

Small molecular tyrosine kinase inhibitors (smTKIs) are in the centre of the very quickly
expanding area of personalized chemotherapy and oral applicability thereof. The number of …