Coronary arterial disease (CAD) is the leading cause of mortality in the world.
Hyperuricemia has recently emerged as a novel independent risk factor of CAD, in addition …

Hyperuricemia (HUA) may lead to myocardial cell damage, thereby promoting the
occurrence and adverse outcomes of heart diseases. In this review, we discuss the latest …

Attribute-based medicine is essential for patient-centered medicine. To date, the groups of
patients with chronic kidney disease (CKD) requiring urate-lowering therapy are clinically …

Accumulating evidence suggests that high serum uric acid (UA) is associated with left
ventricular (LV) dysfunction. Although xanthine oxidase (XO) activation is a critical regulatory …

Aims Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular
events and exhibit myocardial changes including left ventricular (LV) hypertrophy and …

The incidence of heart failure (HF) is increasing and is associated with a poor prognosis.
Moreover, HF often coexists with renal dysfunction and is associated with a worsened …

Aluminum (Al) is a ubiquitous xenobiotic with known toxicity for both humans and animals.
Our study was conducted to investigate the protective role of febuxostat (Feb) against …

The cardiorenal syndrome (CRS) is described as a multi‐organ disease encompassing
bidirectionally heart and kidney. In CRS type 4, chronic kidney disease (CKD) leads to …

Xanthine oxidase (XO) contributes to oxidative stress and vascular disease. Hyperuricemia
and gout are common in patients with chronic kidney disease (CKD), a population at …

Oxidative stress plays a key role in chronic kidney disease (CKD) development and
progression, inducing kidney cell damage, inflammation, and fibrosis. However, effective …