Approximately 8,000 persons survive spinal cord injury (SCI) each year in the United States.
About 200,000 Americans have spinal cord injuries, and this number is increasing as life …

Study design: Literature review. Objectives: Critical review of the literature published on the
physiological alterations caused by spinal cord injury (SCI) and their effect on the …

Symptoms of neuropathic spinal cord injury (SCI) pain include cutaneous hypersensitivity
and spontaneous pain below the level of the injury. Riluzole, an FDA-approved drug for the …

Object The aim of this paper was to characterize individual and population pharmacokinetics
of enterally administered riluzole in a Phase 1 clinical trial of riluzole as a neuroprotective …

Objectives: The rate and completeness of gastric emptying (GE) are major determinants of
the bioavailability of oral medication, and the efficiency of gastric emptying is highly …

Spinal cord injury (SCI) produces multiple systemic and metabolic alterations. Although
some systemic alterations could be associated with ischemic organ damage, little is known …

Spine disorders are commonly encountered in the practice of anesthesiology. Effective
treatment often involves surgical intervention. Irrespective of the etiology, a fundamental …

There are currently no proven effective treatments that can improve recovery of function in
spinal cord injury (SCI) patients. Many therapeutic compounds have shown promise in pre …

This paper investigates the transport of drugs delivered by direct injection into the
cerebrospinal fluid (CSF) that fills the intrathecal space surrounding the spinal cord …

IMPLICATIONS: Small-dose theophylline might be an interesting adjunct for the treatment of
spinal cord injury-evoked bradycardia and respiratory dysfunction. Bradycardia and …