Protein lysine acetylation by p300/CBP

BM Dancy, PA Cole - Chemical reviews, 2015 - ACS Publications
Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase
encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP …

The ins and outs of tubulin acetylation: more than just a post-translational modification?

D Perdiz, R Mackeh, C Poüs, A Baillet - Cellular signalling, 2011 - Elsevier
Microtubules are highly dynamic polymers of α/β tubulin heterodimers that play key roles in
cell division and in organizing cell cytoplasm. Although they have been discovered more …

Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae

P Henriksen, SA Wagner, BT Weinert, S Sharma… - Molecular & Cellular …, 2012 - ASBMB
Post-translational modification of proteins by lysine acetylation plays important regulatory
roles in living cells. The budding yeast Saccharomyces cerevisiae is a widely used …

Proteome-Wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation

BT Weinert, SA Wagner, H Horn, P Henriksen… - Science …, 2011 - science.org
Posttranslational modification of proteins by acetylation and phosphorylation regulates most
cellular processes in living organisms. Surprisingly, the evolutionary conservation of …

Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice

KS Fritz, JJ Galligan, MD Hirschey… - Journal of proteome …, 2012 - ACS Publications
Mitochondrial protein hyperacetylation is a known consequence of sustained ethanol
consumption and has been proposed to play a role in the pathogenesis of alcoholic liver …

Mycobacterium tuberculosis Eis protein initiates suppression of host immune responses by acetylation of DUSP16/MKP-7

KH Kim, DR An, J Song, JY Yoon… - Proceedings of the …, 2012 - National Acad Sciences
The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis.
Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of …

Histone modifiers in cancer: friends or foes?

I Cohen, E Poręba, K Kamieniarz… - Genes & …, 2011 - journals.sagepub.com
Covalent modifications of histones can regulate all DNA-dependent processes. In the last
few years, it has become more and more evident that histone modifications are key players …

Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription

R Rajendran, R Garva… - BioMed Research …, 2011 - Wiley Online Library
Transcription is regulated by acetylation/deacetylation reactions of histone and nonhistone
proteins mediated by enzymes called KATs and HDACs, respectively. As a major …

Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction

JY Lu, YY Lin, JC Sheu, JT Wu, FJ Lee, Y Chen, MI Lin… - Cell, 2011 - cell.com
Acetylation of histone and nonhistone proteins is an important posttranslational modification
affecting many cellular processes. Here, we report that NuA4 acetylation of Sip2, a …

The tale of protein lysine acetylation in the cytoplasm

K Sadoul, J Wang, B Diagouraga… - BioMed Research …, 2011 - Wiley Online Library
Reversible posttranslational modification of internal lysines in many cellular or viral proteins
is now emerging as part of critical signalling processes controlling a variety of cellular …