Rpd3 is a class I histone deacetylase that reverses lysine acetylation thus influencing
cellular processes and functions. However, its role in fungal insect pathogens has not been …

Protein acetylation plays many roles within living cells, modulating metabolism, signaling
and cell response to environmental stimuli, as well as having an impact on pathological …

Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)
are the major incretin hormones that exert insulinotropic and anti-apoptotic actions on …

Hsp70 is a highly conserved molecular chaperone critical for the folding of new and
denatured proteins. While traditional models state that cells respond to stress by …

Three diastereomers of burkholdac B were prepared by total synthesis, enabling the full
stereochemical assignment of the natural product. It is proposed that burkholdac B is …

Objective—To address the role of epigenetic enzymes in the process of arterial
vasorelaxation and nitrate tolerance, in vitro and in vivo experiments were performed in the …

DNA and other biomolecules are subjected to damaging chemical reactions during normal
physiological processes and in states of pathophysiology caused by endogenous and …

A major focus of systems biology is to characterize interactions between cellular
components, in order to develop an accurate picture of the intricate networks within …

Acetylation is a post-translational modification that regulates the activity of enzymes
fundamentally involved in cellular and mitochondrial bioenergetic metabolism. NAD+ …

Long chain acyl-CoA synthetase 1 (ACSL1) contributes 50 to 90% of total ACSL activity in
liver, adipose tissue, and heart and appears to direct the use of long chain fatty acids for …