摘要目的了解组蛋白去乙酰化酶6 (HDAC6) 在胃癌组织中的表达及临床意义.
方法采用组织芯片与免疫组织化学SP 法检测75 例胃癌组织, 15 例癌旁正常组织和18 例中 …

For children with acute lymphoblastic leukemia (ALL) who relapse, prognosis is poor and
novel therapeutic strategies are needed. In the last decade, it has become apparent that ALL …

Abstract​​: Protein acetylation is a widespread post-translational modification that is
implicated in many cellular processes. Emergent technologies such as mass spectrometry …

This book focuses on the advantages and disadvantages of each of the commonly used
quantitative proteomic methods in terms of accuracy, sensitivity, and reproducibility. It also …

Sirtuins are NAD+-dependent deacetylases and ADP ribosyltransferases that are activated
under stress conditions such as calorie restriction and starvation. Boron, which is mostly …

Kardiovaskuläre Erkrankungen stellen weltweit eine der häufigsten Todesursachen dar. Die
Rolle des weiblichen Geschlechtshormons Östrogen (E2) bei kardiovaskulären …

Protein lysine acetylation is a reversible posttranslational modification and plays a pivotal
role in a broad array of physiological functions. In our study, a strategy combining …

The human genome with 20.000 to 25.000 coding regions (International Human Genome
Sequencing, 2004) is much less complex than the human proteome of more than one million …

4 ABSTRACT Interleukin-1α (IL-1α) is a pleiotropic cytokine and a key mediator of host
immune response. It is synthesised as a 31-kDa precursor, that is cleaved by the cysteine …

Acetylation is a post-translational modification that regulates the activity of enzymes
fundamentally involved in cellular and mitochondrial bioenergetic metabolism. NAD+ …