Polypharmacy is a major challenge in healthcare for older people, and is associated with
increased risks of adverse outcomes, such as delirium, falls, frailty, cognitive impairment and …

The way of plant sterols transformation and their benefits for humans is still a question under
the massive continuing revision. In fact, there are no receptors for binding with sterols in …

The brain-specific enzyme CYP46A1 controls cholesterol turnover by converting cholesterol
into 24 S-hydroxycholesterol (24OH). Dysregulation of brain cholesterol turnover and …

Abstract The oxysterol 27-hydroxycholesterol (27OHC) is produced by the enzyme sterol 27-
hydroxylase (Cyp27A1) and is mainly catabolized to 7α-Hydroxy-3-oxo-4-cholestenoic acid …

Aging, polypharmacy (concurrent use of≥ 5 medications), and functional impairment are
global healthcare challenges. However, knowledge of the age/sex-specific effects of …

Precision medicine is an approach to maximise the effectiveness of disease treatment and
prevention and minimise harm from medications by considering relevant demographic …

Males and females may respond differently to medications, yet knowledge about sexual
dimorphisms in the effects of polypharmacy remains limited, particularly in aging. This study …

Abstract Oxidized cholesterol metabolite 27‐hydroxycholesterol (27‐OH) is a potential link
between hypercholesterolemia and neurodegenerative diseases since unlike peripheral …

Preclinical models have been the backbone of translational research for more than a
century. Rats and mice are critical models in the preliminary stages of drug testing, both for …

With ageing of the population worldwide and discovery of new medications for prevention
and management of age-related conditions, there is increasing use of medications by older …