2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …

Cytogenetics has determined the incidence and prognostic significance of chromosomal
abnormalities in acute lymphoblastic leukaemia (ALL). The development of fluorescence in …

Conventional karyotypes performed before any treatment in 208 patients with multiple
myeloma were reviewed by the Groupe Français de Cytogénétique Hématologique. A total …

Over the last decade, fluorescence in situ hybridization (FISH) has become a firmly
established technique in the diagnosis and assessment of lymphoid malignancies …

The development of molecular hybridization techniques such as fluorescence in situ
hybridization (FISH) has had a major Impact on efforts to detect and characterize the genetic …

It is often difficult to distinguish myelodysplastic syndrome (MDS) from severe aplastic
anemia (SAA) because both can present with profoundly hypocellular bone marrows. The …

Interphase fluorescence in situ hybridization (iFISH) was used independently to reveal
chromosomal abnormalities of prognostic importance in a large, consecutive series of …

Acute lymphoblastic leukemia (ALL) is classified as B‐lineage ALL (B‐ALL) and T‐lineage
ALL (T‐ALL). The incidence of ALL is almost three times higher in white than black children …

An important factor in the diagnosis of acute lymphoblastic leukemia (ALL) is that karyotype
is an independent prognostic indicator, with an impact on the choice of treatment. Outcome …

In childhood acute lymphoblastic leukaemia (ALL), cytogenetics plays an essential role in
diagnosis and prediction of outcome. Conventional cytogenetic analysis, complemented by …