Matrix metalloproteinase in abdominal aortic aneurysm and aortic dissection

EM Maguire, SWA Pearce, R Xiao, AY Oo, Q Xiao - Pharmaceuticals, 2019 - mdpi.com
Abdominal Aortic Aneurysm (AAA) affects 4–5% of men over 65, and Aortic Dissection (AD)
is a life-threatening aortic pathology associated with high morbidity and mortality. Initiators of …

Molecular mechanisms of thoracic aortic dissection

D Wu, YH Shen, L Russell, JS Coselli… - Journal of Surgical …, 2013 - Elsevier
Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …

Aetiology and management of hereditary aortopathy

A Verstraeten, I Luyckx, B Loeys - Nature Reviews Cardiology, 2017 - nature.com
Aortic aneurysms are a major health problem because they account for 1–2% of all deaths in
the Western population. Although abdominal aortic aneurysms (AAAs) are more prevalent …

Cardiovascular disease in ageing: an overview on thoracic aortic aneurysm as an emerging inflammatory disease

C Pisano, CR Balistreri, A Ricasoli… - Mediators of …, 2017 - Wiley Online Library
Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection
was originally described by Erdheim as a noninflammatory lesion related to the loss of …

Non‐coding RNAs in aortic dissection: from biomarkers to therapeutic targets

M Cheng, Y Yang, H Xin, M Li, T Zong… - Journal of cellular …, 2020 - Wiley Online Library
Aortic dissection (AD) is the rupture of the aortic intima, causing the blood in the cavity to
enter the middle of the arterial wall. Without urgent and proper treatment, the mortality rate …

The role of ADAMTS-4 in atherosclerosis and vessel wall abnormalities

R Novak, S Hrkac, G Salai, J Bilandzic, L Mitar… - Journal of vascular …, 2022 - karger.com
Extracellular matrix proteins are regulated by metzincin proteases, like the disintegrin
metalloproteinases with thrombospondin motifs (ADAMTS) family members. This review …

AKT2 confers protection against aortic aneurysms and dissections

YH Shen, L Zhang, P Ren, MT Nguyen, S Zou… - Circulation …, 2013 - Am Heart Assoc
Rationale: Aortic aneurysm and dissection (AAD) are major diseases of the adult aorta
caused by progressive medial degeneration of the aortic wall. Although the overproduction …

Host-derived cytotoxic agents in chronic inflammation and disease progression

J Arnhold - International Journal of Molecular Sciences, 2023 - mdpi.com
At inflammatory sites, cytotoxic agents are released and generated from invading immune
cells and damaged tissue cells. The further fate of the inflammation highly depends on the …

Gene expression profiling of acute type A aortic dissection combined with in vitro assessment

N Kimura, K Futamura, M Arakawa… - European Journal of …, 2017 - academic.oup.com
OBJECTIVES The mechanisms underlying aortic dissection remain to be fully elucidated.
We aimed to identify key molecules driving dissection through gene expression profiling …

Neutrophil to lymphocyte ratio: a novel marker for predicting hospital mortality of patients with acute type A aortic dissection

ME Kalkan, AK Kalkan, A Gündeş, M Yanartaş… - …, 2017 - journals.sagepub.com
Introduction: The inflammatory process has been reported to be associated with aortic
dissection (AD) from the development to the prognosis. The aim of the study was to …