The Angiotensin-(1–12)/Chymase axis as an alternate component of the tissue renin angiotensin system

CM Ferrario, L Groban, H Wang, CP Cheng… - Molecular and cellular …, 2021 - Elsevier
The identification of an alternate extended form of angiotensin I composed of the first twelve
amino acids at the N-terminal of angiotensinogen has generated new knowledge of the …

Does the naked emperor parable apply to current perceptions of the contribution of renin angiotensin system inhibition in hypertension?

CM Ferrario, A Saha, JL VonCannon… - Current Hypertension …, 2022 - Springer
Abstract Purpose of Review To address contemporary hypertension challenges, a critical
reexamination of therapeutic accomplishments using angiotensin converting enzyme …

Angiotensin (1–12) in humans with normal blood pressure and primary hypertension

CM Ferrario, SR Iyer, JC Burnett Jr, S Ahmad… - …, 2021 - Am Heart Assoc
The importance of canonical versus noncanonical mechanisms for the generation of
angiotensins remains a major challenge that, in part, is heavily swayed by the relative …

Immunoneutralization of human angiotensin-(1-12) with a monoclonal antibody in a humanized model of hypertension

CM Ferrario, JL VonCannon, J Zhang, JP Figueroa… - Peptides, 2022 - Elsevier
We engineered a monoclonal antibody (mAb) against the human C-terminus of angiotensin-
(1–12)[h-Ang-(1–12)] and performed a biochemical characterization in concert with direct in …

Clofibrate, a peroxisome proliferator–activated receptor-alpha (PPARα) agonist, and its molecular mechanisms of action against sodium fluoride–induced toxicity

AA Oyagbemi, OA Adejumobi, TA Jarikre… - … Trace Element Research, 2022 - Springer
Sodium fluoride (NaF) is one of the neglected environmental pollutants. It is ubiquitously
found in the soil, water, and environment. Interestingly, fluoride has been extensively utilized …

Is chymase 1 a therapeutic target in cardiovascular disease?

CM Ferrario, S Ahmad, R Speth… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Non-angiotensin converting enzyme mechanisms of angiotensin II production
remain underappreciated in part due to the success of current therapies to ameliorate the …

[HTML][HTML] Calcium regulation on the atrial regional difference of collagen production activity in atrial fibrogenesis

CC Chung, YK Lin, YC Chen, YH Kao, YH Yeh… - Biomedicines, 2021 - mdpi.com
Background: Atrial fibrosis plays an important role in the genesis of heart failure and atrial
fibrillation. The left atrium (LA) exhibits a higher level of fibrosis than the right atrium (RA) in …

[HTML][HTML] Atrial angiotensin-(1-12)/chymase expression data in patient of heart diseases

H Wang, J Varagic, S Nagata, ND Kon, S Ahmad… - Data in Brief, 2020 - Elsevier
The data presented here are related to the research article entitled “Differential expression
of the angiotensin-(1-12)[Ang-(1-12)]/chymase axis in human atrial tissue [1]. We have …

[HTML][HTML] Regional Diversities in Fibrogenesis Weighed as a Key Determinant for Atrial Arrhythmogenesis

CC Chung, CG Chin, YK Lin, YC Chen, WL Cheng… - Biomedicines, 2021 - mdpi.com
Atrial fibrosis plays a key role in atrial myopathy, resulting in the genesis of atrial fibrillation
(AF). The abnormal distribution of fibrotic tissue, electrical coupling, paracrine interactions …

Renin–angiotensin–aldosterone system inhibitors. New and old approaches

CM Ferrario, JL VonCannon, KN Wright, S Ahmad - Angiotensin, 2023 - Elsevier
Renin–angiotensin–aldosterone system inhibitors. New and old approaches - ScienceDirect
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