Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide.
However, colon cancer incidence and mortality is declining over the past decade owing to …

Septins are an integral component of the cytoskeleton, assembling into higher-order
oligomers and filamentous polymers that associate with actin filaments, microtubules and …

Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

Animal cell cytokinesis requires a contractile ring of crosslinked actin filaments and myosin
motors. How contractile rings form and are stabilized in dividing cells remains unclear. We …

Cilia are conserved, microtubule-based cell surface projections that emanate from basal
bodies, membrane-docked centrioles. The beating of motile cilia and flagella enables cells …

Colorectal cancer (CRC), one of the leading causes of death among cancer patients, is a
heterogeneous disease and is characterized by diversions in multiple molecular pathways …

Septins are GTP binding proteins considered to be novel components of the cytoskeleton.
They polymerize into filaments based on hexameric or octameric core particles in which two …

Septins are GTP-binding proteins that form filaments and higher-order structures on the cell
cortex of eukaryotic cells and associate with actin and microtubule cytoskeletal networks …

The actin and microtubule cytoskeletons comprise a variety of networks with distinct
architectures, dynamics and protein composition. A fundamental question in eukaryotic cell …