Simple Summary Despite breakthroughs in medicine, cancer remains one of the most feared
diseases. Traditionally, chemotherapies have been the treatment of choice. However …

Growth differentiation factor‐15 (GDF‐15) is a stress responsive cytokine. It is highly
expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Although nerve cell death is the hallmark of many neurological diseases, the processes
underlying this death are still poorly defined. However, there is a general consensus that …

The polo-like kinase 1 (PLK1) acts in concert with cyclin-dependent kinase 1–cyclin B1 and
Aurora kinases to orchestrate a wide range of critical cell cycle events. Because PLK1 has …

The cap'n'collar (CNC) bZIP transcription factor Nrf2 controls expression of genes for
antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes, drug transporters …

Research programmes on oxidative stress and hormesis are wide ranging. Biomedical and
toxicological sciences have traditionally centralised such research, but in the last years we …

Currently, the oxidative stress (or free radical) theory of aging is the most popular
explanation of how aging occurs at the molecular level. While data from studies in …