[HTML][HTML] TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress
H Jung, MJ Kim, DO Kim, WS Kim, SJ Yoon, YJ Park… - Cell metabolism, 2013 - cell.com
Reactive oxygen species (ROS) are critical determinants of the fate of hematopoietic stem
cells (HSCs) and hematopoiesis. Thioredoxin-interacting protein (TXNIP), which is induced …
cells (HSCs) and hematopoiesis. Thioredoxin-interacting protein (TXNIP), which is induced …
Isoquercitrin is the most effective antioxidant in the plant Thuja orientalis and able to counteract oxidative-induced damage to a transformed cell line (RGC-5 cells)
SH Jung, BJ Kim, EH Lee, NN Osborne - Neurochemistry international, 2010 - Elsevier
The shrub Thuja orientalis is extensively used as a herbal medicine in Korea and China. In
the present study extracts of the plant were subjected to fractionation and purification, with …
the present study extracts of the plant were subjected to fractionation and purification, with …
The role of Plk3 in oncogenesis
C Helmke, S Becker, K Strebhardt - Oncogene, 2016 - nature.com
The polo-like kinases (Plks) encompass a family of five serine/threonine protein kinases that
play essential roles in many cellular processes involved in the control of the cell cycle …
play essential roles in many cellular processes involved in the control of the cell cycle …
[HTML][HTML] Induction of miR-29a by saturated fatty acids impairs insulin signaling and glucose uptake through translational repression of IRS-1 in myocytes
WM Yang, HJ Jeong, SY Park, W Lee - FEBS letters, 2014 - Elsevier
MicroRNAs have been shown to play an important role in insulin signaling but their
biological function in insulin resistance induced by saturated fatty acids (SFA) remains …
biological function in insulin resistance induced by saturated fatty acids (SFA) remains …
Mitochondrial thioredoxin reductase inhibition, selenium status, and Nrf-2 activation are determinant factors modulating the toxicity of mercury compounds
The thioredoxin system has essential functions in the maintenance of cellular redox
homeostasis in the cytosol, nucleus, and mitochondria. Thioredoxin (Trx) and thioredoxin …
homeostasis in the cytosol, nucleus, and mitochondria. Thioredoxin (Trx) and thioredoxin …
[HTML][HTML] Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2
JL Qin, WY Shen, ZF Chen, LF Zhao, QP Qin, YC Yu… - Scientific reports, 2017 - nature.com
Three new oxoaporphine Co (II), Ni (II) and Zn (II) complexes 1–3 have been synthesized
and fully characterized. 1–3 have similar mononuclear structures with the metal and ligand …
and fully characterized. 1–3 have similar mononuclear structures with the metal and ligand …
Accelerated decline in cognition in a mouse model of increased oxidative stress
S Logan, GH Royce, D Owen, J Farley… - Geroscience, 2019 - Springer
Mice deficient in the antioxidant enzyme Cu/Zn-superoxide dismutase (Sod1KO mice) have
a significant reduction in lifespan, exhibit many phenotypes of accelerated aging, and have …
a significant reduction in lifespan, exhibit many phenotypes of accelerated aging, and have …
[HTML][HTML] Nrf2 null enhances UVB-induced skin inflammation and extracellular matrix damages
Nrf2 plays a critical role in defending against oxidative stress and inflammation. We
previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced …
previously reported that Nrf2 confers protection against ultraviolet-B (UVB)-induced …
Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI
D Zou, R Ganugula, M Arora… - American Journal …, 2019 - journals.physiology.org
The popular anticancer drug cisplatin causes many adverse side effects, the most serious of
which is acute kidney injury (AKI). Emerging evidence from laboratory and clinical studies …
which is acute kidney injury (AKI). Emerging evidence from laboratory and clinical studies …
[HTML][HTML] Role of growth differentiation factor 15 in lung disease and senescence: potential role across the lifespan
F Al-Mudares, S Reddick, J Ren, A Venkatesh… - Frontiers in …, 2020 - frontiersin.org
Growth Differentiation Factor 15 (GDF15) is a divergent member of transforming growth
factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological …
factor-beta (TGF-β) superfamily and is ubiquitously expressed, under normal physiological …