Background Gray matter (GM) pathology is closely associated with physical and cognitive
impairment in persons with multiple sclerosis (PwMS). Similarly, serum neurofilament light …

Objective The aim of this work was to evaluate the quality of life of patients with multiple
sclerosis and its association with depressive symptoms and physical health. Method A total …

Aging is characterized, amongst other features, by a complex process of cellular
senescence involving both innate and adaptive immunity, called immunosenescence and …

Multiple sclerosis (MS) primarily affects adult females. However, in the last decades, rising
incidence and prevalence have been observed for demographic extremes, such as pediatric …

Stress mechanisms have long been associated with neuronal loss and neurodegenerative
diseases. The origin of cell stress and neuronal loss likely stems from multiple pathways …

Background: The prevalence of elderly patients with MS is increasing, in conjunction with
the ageing general population. This review will examine the principal characteristics of …

Abstract Recombinant interferon (IFN) β-1b was approved by the US Food and Drug
Administration as the first disease-modifying therapy (DMT) for multiple sclerosis (MS) in …

Extracellular vesicles (EVs) represent a new reality for many physiological and pathological
functions as an alternative mode of intercellular communication. This is due to their capacity …

Objective To explore whether age at onset increased over time despite a shortened interval
from the initial clinical demyelinating event to the diagnosis of multiple sclerosis (MS), as …

Telomeres are protective structures at the ends of linear chromosomes. Shortened telomere
lengths (TL) are an indicator of premature biological aging and have been associated with a …