Coronavirus disease 2019–associated coagulopathy

G Lippi, F Sanchis-Gomar, EJ Favaloro, CJ Lavie… - Mayo Clinic …, 2021 - Elsevier
Patients with the severe form of coronavirus disease 2019 (COVID-19) have been frequently
found to suffer from both arterial and venous thrombotic events due to the perpetuation of a …

Antiphospholipid syndrome

G Ruiz-Irastorza, M Crowther, W Branch… - The Lancet, 2010 - thelancet.com
The antiphospholipid syndrome causes venous, arterial, and small-vessel thrombosis;
pregnancy loss; and preterm delivery for patients with severe pre-eclampsia or placental …

Pathogenesis of antiphospholipid syndrome: understanding the antibodies

PL Meroni, MO Borghi, E Raschi… - Nature Reviews …, 2011 - nature.com
Antiphospholipid antibodies (aPL) are both diagnostic markers for, and pathogenic drivers
of, antiphospholipid syndrome (APS). Although the presence of aPL is a necessary pre …

Thrombotic antiphospholipid syndrome: a practical guide to diagnosis and management

Z Sayar, R Moll, D Isenberg, H Cohen - Thrombosis research, 2021 - Elsevier
Thrombotic antiphospholipid syndrome (APS) is characterised by venous, arterial and/or
small vessel thrombosis in the context of persistently positive antiphospholipid antibodies …

Antiphospholipid syndrome: role of vascular endothelial cells and implications for risk stratification and targeted therapeutics

MT Corban, A Duarte-Garcia, RD McBane… - Journal of the American …, 2017 - jacc.org
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous
thromboembolism, arterial thrombosis, and obstetric morbidities in the setting of persistently …

Definition of human autoimmunity—autoantibodies versus autoimmune disease

A Lleo, P Invernizzi, B Gao, M Podda, ME Gershwin - Autoimmunity reviews, 2010 - Elsevier
The critical function of the immune system is to discriminate self from non-self. Tolerance
against self-antigens is a highly regulated process and, in order to maintain it, the immune …

Obstetric and vascular antiphospholipid syndrome: same antibodies but different diseases?

PL Meroni, MO Borghi, C Grossi… - Nature Reviews …, 2018 - nature.com
Recurrent thrombosis and miscarriages are the main clinical manifestations of
antiphospholipid syndrome (APS). Although most patients display both clinical signs, some …

Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots

ML Tung, B Tan, R Cherian… - … advances in practice, 2021 - academic.oup.com
As the coronavirus disease 2019 (COVID-19) pandemic, which is caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide, it …

[HTML][HTML] β2‐Glycoprotein I: evolution, structure and function

PG De Groot, JCM Meijers - Journal of Thrombosis and Haemostasis, 2011 - Elsevier
Summary β 2‐Glycoprotein I (β 2‐GPI) is a protein that circulates in blood at high
concentrations. The function of β 2‐GPI has long been an enigma. More than 20 years ago …

The antiphospholipid syndrome: from pathophysiology to treatment

S Negrini, F Pappalardo, G Murdaca, F Indiveri… - Clinical and …, 2017 - Springer
Antiphospholipid antibody syndrome (APS) is an autoimmune acquired thrombophilia
characterized by recurrent thrombosis and pregnancy morbidity in the presence of …