Anti-β2GPI antibodies stimulate endothelial cell microparticle release via a nonmuscle myosin II motor protein-dependent pathway

V Betapudi, G Lominadze, L Hsi… - Blood, The Journal …, 2013 - ashpublications.org
The antiphospholipid syndrome is characterized by thrombosis and recurrent fetal loss in
patients with antiphospholipid antibodies (APLAs). Most pathogenic APLAs are directed …

Autoantibodies against a complement component 1 q subcomponent contribute to complement activation and recurrent thrombosis/pregnancy morbidity in anti …

K Oku, O Amengual, R Hisada, K Ohmura… - …, 2016 - academic.oup.com
Objective. To investigate the prevalence and significance of the autoantibodies against
complement component 1 q subcomponent (C1q) in patients with APS. Methods. In all, 40 …

[HTML][HTML] Trophoblast cell function in the antiphospholipid syndrome

S Vrzić Petronijević, A Vilotić, Ž Bojić-Trbojević… - Biomedicines, 2023 - mdpi.com
Antiphospholipid syndrome (APS) is a complex thrombo-inflammatory autoimmune disease
characterized by the presence of antiphospholipid antibodies (aPL). Women with APS are at …

[HTML][HTML] The relationship between mean platelet volume and thrombosis recurrence in patients diagnosed with antiphospholipid syndrome

J Rupa-Matysek, L Gil, E Wojtasińska… - Rheumatology …, 2014 - Springer
Increased mean platelet volume (MPV) is associated with platelet reactivity and is a
predictor of cardiovascular risk and unprovoked venous thromboembolism. The aim of our …

The clinical significance of posttranslational modification of autoantigens

MG Zavala-Cerna, EA Martínez-García… - Clinical reviews in …, 2014 - Springer
Posttranslational modifications (PTMs) are defined as covalent modifications occurring in a
specific protein amino acid in a time-and signal-dependent manner. Under physiological …

Decreased expression of heparin‐binding epidermal growth factor–like growth factor as a newly identified pathogenic mechanism of antiphospholipid‐mediated …

N Di Simone, R Marana, R Castellani… - Arthritis & …, 2010 - Wiley Online Library
Objective Heparin‐binding epidermal growth factor–like growth factor (HB‐EGF) plays a role
in blastocyst implantation and is down‐regulated in preeclampsia and in hypertensive …

The pathogenesis of neural injury in animal models of the antiphospholipid syndrome

A Katzav, Y Shoenfeld, J Chapman - Clinical reviews in allergy & …, 2010 - Springer
Circulating antiphospholipid antibodies (aPL) are associated with central nervous system
dysfunction in antiphospholipid syndrome (APS) patients and in a mouse model of APS. We …

[HTML][HTML] Clinical features, diagnosis, and management of the antiphospholipid syndrome

RCW Wong, EJ Favaloro - Seminars in thrombosis and …, 2008 - thieme-connect.com
Almost 30 years after it was first described as a discrete clinical entity, the antiphospholipid
syndrome (APS) remains a challenge for clinicians in a wide range of specialities. There …

Inhibition of nitric oxide and antiphospholipid antibody-mediated thrombosis

C Mineo - Current rheumatology reports, 2013 - Springer
The antiphospholipid syndrome (APS) is characterized by recurrent vascular thrombosis,
thrombocytopenia, and fetal loss occurring in the presence of antiphospholipid antibodies …

[HTML][HTML] Hydroxychloroquine partially prevents endothelial dysfunction induced by anti-beta-2-GPI antibodies in an in vivo mouse model of antiphospholipid syndrome

G Urbanski, A Caillon, C Poli, G Kauffenstein… - PLoS …, 2018 - journals.plos.org
Background Antiphospholipid syndrome is associated with endothelial dysfunction, which
leads to thrombosis and early atheroma. Given that hydroxychloroquine has anti-thrombotic …