Cancer-associated thrombosis (including venous thromboembolism (VTE) and arterial
events) is highly consequential for patients with cancer and is associated with worsened …

Combinations of proinflammatory and procoagulant reactions are the unifying principle for a
variety of disorders affecting the cardiovascular system. The factor XII–driven contact system …

Hemocompatibility of biomaterials in contact with the blood of patients is a prerequisite for
the short-and long-term applications of medical devices such as cardiovascular stents …

Factor XI (FXI) is the zymogen of a plasma protease, factor XIa (FXIa), that contributes to
thrombin generation during blood coagulation by proteolytic activation of several …

To date the pathophysiology of COVID-19 remains unclear: this represents a factor
determining the current lack of effective treatments. In this paper, we hypothesized a …

The contact system is a potent procoagulant and proinflammatory plasma protease cascade
that is initiated by binding (“contact”)-induced, auto-activation of factor XII zymogen. Formed …

Proteases are a diverse group of hydrolytic enzymes, ranging from single-domain catalytic
molecules to sophisticated multi-functional macromolecules. Human proteases are divided …

Toll-like receptor 4 (TLR4) are part of the innate immune system. They are capable of
recognizing pathogen-associated molecular patterns (PAMPS) of microbes, and damage …

Mast cells (MCs) have relevant participation in inflammatory and vascular hyperpermeability
events, responsible for the action of the kallikrein–kinin system (KKS), that affect patients …

The plasma protein factor XII (FXII) is the liver-derived zymogen of the serine protease FXIIa
that initiates an array of proteolytic cascades. Zymogen activation, enzymatic FXIIa activity …