Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

The human epidermal growth factor receptor (EGFR) family consists of four members that
belong to the ErbB lineage of proteins (ErbB1–4). These receptors consist of a glycosylated …

Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement
on SRC function. However, a significant body of work has defined Src family kinases as key …

During the last few decades, improvements in the planning and application of radiotherapy
in combination with surgery and chemotherapy resulted in increased survival rates of tumor …

A main limitation of therapies that selectively target kinase signalling pathways is the
emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the …

EGF receptor (EGFR)-targeted monoclonal antibodies are effective in a subset of metastatic
colorectal cancers. Inevitably, all patients develop resistance, which occurs through …

To achieve highly effective treatment to diseases, successful delivery of drugs with a carrier
into the specific organelles (nucleus, mitochondria, lysosomes, etc.) is of great importance …

The ERBB family of receptor tyrosine kinases has a central role in the tumorigenesis of many
types of solid tumour. Various therapeutics targeting these receptors have been approved …

Background Triple-negative breast cancer (TNBC) is a heterogeneous, aggressive
phenotype of breast cancer with associated chemoresistance. The development of chemo-or …

The discovery of mutant KRAS as a predictor of resistance to epidermal growth-factor
receptor (EGFR) monoclonal antibodies brought a major change in the treatment of …