[HTML][HTML] Recent advances on the role of EGFR tyrosine kinase inhibitors in the management of NSCLC with uncommon, non exon 20 insertions, EGFR mutations
The first-line treatment of choice for patients with epidermal growth factor receptor (EGFR)
mutation-positive non-small cell lung cancer (NSCLC) is an EGFR tyrosine kinase inhibitor …
mutation-positive non-small cell lung cancer (NSCLC) is an EGFR tyrosine kinase inhibitor …
ctDNA-based liquid biopsy of cerebrospinal fluid in brain cancer
L Escudero, F Martínez-Ricarte, J Seoane - Cancers, 2021 - mdpi.com
Simple Summary The optimal treatment and management of patients with brain cancer
depend on the molecular characteristics of their tumour. Since the tumour changes with time …
depend on the molecular characteristics of their tumour. Since the tumour changes with time …
Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring
D Reita, L Pabst, E Pencreach, E Guérin, L Dano… - Cancers, 2021 - mdpi.com
Simple Summary Non-small cell lung cancer (NSCLC) is the most common cancer in the
world. For common EGFR mutations, treatment is based on different inhibitors. Despite the …
world. For common EGFR mutations, treatment is based on different inhibitors. Despite the …
Genomic comparison between cerebrospinal fluid and primary tumor revealed the genetic events associated with brain metastasis in lung adenocarcinoma
Z Deng, L Cui, P Li, N Ren, Z Zhong, Z Tang… - Cell Death & …, 2021 - nature.com
Lung adenocarcinoma (LUAD) is most common pathological type of lung cancer. LUAD with
brain metastases (BMs) usually have poor prognosis. To identify the potential genetic factors …
brain metastases (BMs) usually have poor prognosis. To identify the potential genetic factors …
Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need
G Pretelli, CC Spagnolo, G Ciappina… - International Journal of …, 2023 - mdpi.com
The majority of epidermal growth factor receptor (EGFR) mutations (85–90%) are exon 19
deletions and L858R point mutations of exon 21, characterized by high sensitivity to EGFR …
deletions and L858R point mutations of exon 21, characterized by high sensitivity to EGFR …
Efficacy and safety of dacomitinib in treatment-naïve patients with advanced NSCLC harboring uncommon EGFR mutation: an ambispective cohort study
X Pu, Y Zhou, Y Kong, B Chen, A Yang, J Li, K Li, Y Xu… - Bmc Cancer, 2023 - Springer
Background About 10% of non-small cell lung cancer (NSCLC) patients with epidermal
growth factor receptor (EGFR) mutations are harbored as uncommon mutations. This study …
growth factor receptor (EGFR) mutations are harbored as uncommon mutations. This study …
Evaluating infectious, neoplastic, immunological, and degenerative diseases of the central nervous system with cerebrospinal fluid-based next-generation sequencing
KI Tsamis, H Sakkas, A Giannakis, HS Ryu… - Molecular Diagnosis & …, 2021 - Springer
Cerebrospinal fluid (CSF) is a clear and paucicellular fluid that circulates within the
ventricular system and the subarachnoid space of the central nervous system (CNS), and …
ventricular system and the subarachnoid space of the central nervous system (CNS), and …
Clinical outcomes of advanced non-small cell lung cancer patients harboring distinct subtypes of EGFR mutations and receiving first-line tyrosine kinase inhibitors …
Y Zeng, T Guo, Y Zhou, Y Zhao, L Chu, X Chu, X Yang… - BMC cancer, 2022 - Springer
Background The clinical features, survival outcomes and patterns of treatment failure of
advanced non-small cell lung cancer (NSCLC) patients harboring distinct subtypes of EGFR …
advanced non-small cell lung cancer (NSCLC) patients harboring distinct subtypes of EGFR …
Sensitivity analysis of EGFR L861Q mutation to six tyrosine kinase inhibitors
C Liu, Z Wang, Q Liu, G Wu, C Chu, L Li, L An… - Clinical and …, 2022 - Springer
Purpose Lung cancer is one of the most common carcinomas with the highest mortality in
the world. Non-small cell lung carcinoma has a large proportion of epidermal growth factor …
the world. Non-small cell lung carcinoma has a large proportion of epidermal growth factor …
Sequencing of cerebrospinal fluid in non‐small‐cell lung cancer patients with leptomeningeal metastasis: a systematic review
T Gao, F Chen, M Li - Cancer Medicine, 2023 - Wiley Online Library
Leptomeningeal metastasis (LM) refers to the dissemination of malignant cells in the
subarachnoid space, pia, and arachnoid mater and is a severe condition associated with …
subarachnoid space, pia, and arachnoid mater and is a severe condition associated with …