Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

Background: Although cigarette smoking is the major risk factor for lung cancer, only 7% of
female lung cancer patients in Taiwan have a history of smoking. The genetic mechanisms …

Semaphorins are a large family of secreted and membrane-bound molecules that were
initially implicated in the development of the nervous system and in axon guidance. More …

Developing a universal nanoplatform for efficient delivery of various drugs to target sites is
urgent for overcoming various biological barriers and realizing combinational cancer …

Abstract Class 3 semaphorins (SEMA3) were first identified as glycoproteins that negatively
mediate neuronal guidance by binding to neuropilin and repelling neurons away from the …

Sema4D, also known as CD100, is a protein belonging to class IV semaphorin. Its
physiologic roles in the immune and nervous systems have been extensively explored …

Dioscin, a natural steroid saponin, has been widely investigated. However, its anti-cancer
activities on human lung cancer cells are still unknown. In the present paper, the inhibitory …

The epithelial–mesenchymal transition (EMT) and its reversal, mesenchymal–epithelial
transition (MET), are fundamental processes involved in tumor cell invasion and metastasis …

Natural product-derived molecules exhibit potential as anticancer agents. Trilliumoside A, a
new steroidal saponin, was obtained from rhizomes of Trillium govanianum, and its …