[HTML][HTML] Polystyrene microplastics impair the functions of cultured mouse Leydig (TM3) and Sertoli (TM4) cells by inducing mitochondrial-endoplasmic reticulum …

G Grillo, S Falvo, D Latino, GC Baccari… - Ecotoxicology and …, 2024 - Elsevier
Many laboratory studies demonstrated that the exposure to microplastics causes
testosterone deficiency and spermatogenic impairment in mammals; however, the …

Sperm mitochondria dysfunction in response to testicular cancer

M Qasemi, VP Sur, O Simonik… - European Journal of …, 2024 - Wiley Online Library
Testicular cancer is the most common form of cancer in young men of reproductive age and
its incidence is increasing globally. With the currently successful treatment and 95% survival …

[HTML][HTML] Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies

AH Harrath, MA Rahman, SK Bhajan, AK Bishwas… - Cells, 2024 - mdpi.com
Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining
internal stability, plays a crucial function in female reproductive ability. In this review, we …

Sperm mitochondrial content and mitochondrial DNA to nuclear DNA ratio are associated with body mass index and progressive motility

E Moustakli, A Zikopoulos, C Skentou, I Bouba… - Biomedicines, 2023 - mdpi.com
Background: Mitochondrial dysfunction is a risk factor in the pathogenesis of metabolic
disorders. According to the energy requirements, oxidative phosphorylation and the electron …

Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling

AF Odetayo, WJ Adeyemi, LA Olayaki - Frontiers in Endocrinology, 2023 - frontiersin.org
Introduction Bisphenol F (BPF) has been shown to disrupt testicular functions via
perturbation of testicular redox balance, while omega-3 fatty acid (O3FA) has been …

Garden Cress Seed Oil Abrogates Testicular Oxidative Injury and NF-kB-Mediated Inflammation in Diabetic Mice

R Abu-Khudir, GM Badr, HI Abd El-Moaty… - International Journal of …, 2023 - mdpi.com
Diabetes mellitus is a metabolic disorder associated with various complications
encompassing male reproductive dysfunction. The present study aimed to investigate the …

Evaluation of genistein as a mitochondrial modulator and its effects on sperm quality

M Ferigolo, J Nardi, N Freddo, A Ferramosca… - International Journal of …, 2023 - mdpi.com
Phytoestrogens, such as isoflavones, are bioactive compounds found in plants with defense
and protection functions. In the human body, they simulate the behavior of the hormone …

Exposure to Cumulus Cell Secretome Improves Sperm Function: New Perspectives for Sperm Selection In Vitro

FP Luongo, S Perez Casasus, A Haxhiu, F Barbarulo… - Cells, 2023 - mdpi.com
In the literature, there is a well-known correlation between poor semen quality and DNA
sperm integrity, which can turn into negative outcomes in terms of embryo development and …

A short-term high-fat diet alters rat testicular activity and blood-testis barrier integrity through the SIRT1/NRF2/MAPKs signaling pathways

S Falvo, S Minucci, A Santillo, R Senese… - Frontiers in …, 2023 - frontiersin.org
Background Overweight/obesity are metabolic disorder resulting from behavioral,
environmental, and heritable causes. WHO estimates that 50% of adults and 30% of children …

Mitochondrial function and reactive oxygen species production during human sperm capacitation: Unraveling key players

P Irigoyen, S Mansilla, L Castro, A Cassina… - The FASEB …, 2024 - Wiley Online Library
Sperm capacitation is a critical process for male fertility. It involves a series of biochemical
and physiological changes that occur in the female reproductive tract, rendering the sperm …