Autoimmunity develops when self-tolerance mechanisms are failing to protect healthy tissue.
A sustained reaction to self is generated, which includes the generation of effector cells and …

Natural killer (NK) cells are innate lymphoid cells (ILC) known for their ability to recognize
and rapidly eliminate infected or transformed cells. Consequently, NK cells are fundamental …

Reactive microglia associated with the β-amyloid plaques in Alzheimer's disease (AD)
brains initiate a sequence of inflammatory events integral to the disease process. We have …

We investigated the in vivo role of CD69 by analyzing the susceptibility of CD69−/− mice to
tumors. CD69−/− mice challenged with MHC class I− tumors (RMA-S and RM-1) showed …

The acquisition of effector functions by naive CD8 T cells following TCR engagement is
thought to occur sequentially with full functionality being gained only after the initiation of …

The antitumor and immunomodulatory activity of broken-spore of Ganodermalucidum
polysaccharides (Gl-BSP) were investigated in vivo and in vitro. It was showed that Gl-BSP …

Despite the marked success of molecular targeted therapy in lung cancer in this era of
personalized medicine, its efficacy has been limited by the presence of resistance …

Successful Ag activation of naive T helper cells requires at least two signals consisting of
TCR and CD28 on the T cell interacting with MHC II and CD80/CD86, respectively, on APCs …

Background and Objectives: Probiotic supplementation can prevent and alleviate
gastrointestinal and respiratory tract infections in healthy individuals. Markers released from …

Programmed cell death (PCD) is a key phenomenon in the regulation of cell number in
multicellular organisms. We have shown that reduction of endogenous transforming growth …