The last decade has been marked by tremendous progress in our understanding of the cell
biology of mitochondria, with the identification of molecules and mechanisms that regulate …

Selective autophagy of mitochondria, known as mitophagy, is an important mitochondrial
quality control mechanism that eliminates damaged mitochondria. Mitophagy also mediates …

Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less
intuitive but biologically distinct non-degradative roles. One manifestation of these functions …

In the last two decades, extracellular vesicle-mediated communication between cells has
become a major field in cell biology. However, the function of extracellular vesicles is far …

Red blood cells (RBCs) release extracellular vesicles (EVs) including both endosome-
derived exosomes and plasma-membrane-derived microvesicles (MVs). RBC-derived EVs …

Improved understanding of the oxygen-dependent regulation of erythropoiesis has provided
new insights into the pathogenesis of anaemia associated with renal failure and has led to …

With increasing worldwide demand for safe blood, there is much interest in generating red
blood cells in vitro as an alternative clinical product. However, available methods for in vitro …

The first description of reticulocytes was made in 1865 by Wilhelm Heinrich Erb (1840–
1921), a German neurologist who was a leading physician and eminent figure of his time …

Mitochondria are double-membraned highly dynamic organelles; the shape, location and
function of which are determined by a constant balance between opposing fusion and …

The autophagic turnover of mitochondria, termed mitophagy, is thought to play an essential
role in not only maintaining the health of the mitochondrial network but also that of the cell …