Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

The aim of this review is to summarize current available information about the role of
PI3K/AKT/mTOR signaling in head and neck cancer as a potential target for new therapy …

Resistance to treatment is one of the biggest challenges in combating head and neck
squamous cell carcinoma (HNSCC). The concept of resistance, however, is often viewed as …

Blocking the mitogen‐activated protein kinase (MAPK) pathway with the MEK1/2 inhibitor
trametinib has produced promising results in patients with head and neck squamous cell …

Mitochondrial transcriptional factor A (TFAM) acts as a key regulatory to control
mitochondrial DNA (mtDNA); the impact of TFAM and mtDNA in modulating carcinogenesis …

Head and neck squamous cell carcinoma (HNSCC) is featured by notorious EGFR tyrosine
kinase inhibitor (TKI) resistance attributable to activation of parallel pathways. The numerous …

Simple Summary Head and Neck Squamous Cell Carcinoma (HNSCC) is a major threat to
public health around the world. Its occurrence is linked to genetic events and environmental …

AKI induced by CP chemotherapy remains an obstacle during patient treatments.
Extracellular signal-regulated protein kinases 1/2 (ERK), key participants in CP-induced …

Background Head and neck squamous cell carcinoma (HNSCC) patients frequently develop
treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as …

Amongst the most prevalent malignancies worldwide, head and neck squamous cell
carcinoma (HNSCC) is characterized by high morbidity and mortality. The failure of standard …