Update on antiepileptic drugs 2019

BW Abou-Khalil - CONTINUUM: Lifelong Learning in Neurology, 2019 - journals.lww.com
PURPOSE OF REVIEW This article is an update from the article on antiepileptic drug (AED)
therapy published in the last Continuum issue on epilepsy and is intended to cover the vast …

Treatment and care of women with epilepsy before, during, and after pregnancy: a practical guide

B Nucera, F Brigo, E Trinka… - Therapeutic advances in …, 2022 - journals.sagepub.com
Women with epilepsy (WWE) wishing for a child represent a highly relevant subgroup of
epilepsy patients. The treating epileptologist needs to delineate the epilepsy syndrome and …

Current understanding of the mechanism of action of the antiepileptic drug lacosamide

MA Rogawski, A Tofighy, HS White, A Matagne, C Wolff - Epilepsy research, 2015 - Elsevier
The antiepileptic drug lacosamide [(R)-2-acetamido-N-benzyl-3-methoxypropanamide], a
chiral functionalized amino acid, was originally identified by virtue of activity in the mouse …

Update on antiseizure medications 2022

BW Abou-Khalil - CONTINUUM: Lifelong Learning in Neurology, 2022 - journals.lww.com
Abstract EDITOR'S NOTE The article “Update on Antiseizure Medications 2022” by Dr Abou-
Khalil was first published in the February 2016 Epilepsy issue of Continuum: Lifelong …

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide

S Hebeisen, N Pires, AI Loureiro, MJ Bonifácio… - …, 2015 - Elsevier
This study aimed at evaluating the effects of eslicarbazepine, carbamazepine (CBZ),
oxcarbazepine (OXC) and lacosamide (LCM) on the fast and slow inactivated states of …

Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial‐onset seizures: results of a phase III, double‐blind, randomized, placebo‐controlled …

MR Sperling, B Abou‐Khalil, J Harvey, JB Rogin… - …, 2015 - Wiley Online Library
Objective To evaluate the efficacy and safety of adjunctive eslicarbazepine acetate (ESL) in
patients with refractory partial‐onset seizures. Methods This randomized, placebo …

Dosing strategies for antiepileptic drugs: from a standard dose for all to individualised treatment by implementation of therapeutic drug monitoring

CJ Landmark, SI Johannessen, T Tomson - Epileptic Disorders, 2016 - Wiley Online Library
This review focuses on the evolution of approaches to dosing of antiepileptic drugs (AEDs)
in clinical practice through history. There has been a shift in the view of treatment of …

Eslicarbazepine acetate: a new improvement on a classic drug family for the treatment of partial-onset seizures

GL Galiana, AC Gauthier, RH Mattson - Drugs in R&D, 2017 - Springer
Eslicarbazepine acetate is a new anti-epileptic drug belonging to the dibenzazepine
carboxamide family that is currently approved as adjunctive therapy and monotherapy for …

Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial‐onset seizures: a randomized historical‐control …

MR Sperling, J Harvey, T Grinnell, H Cheng, D Blum… - …, 2015 - Wiley Online Library
Objective To assess the efficacy and safety of eslicarbazepine acetate (ESL) as
monotherapy in North American patients with partial‐onset seizures (POS). Methods This …

Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action

P Soares‐da‐Silva, N Pires… - Pharmacology …, 2015 - Wiley Online Library
Eslicarbazepine acetate (ESL) is a once daily antiepileptic drug (AED) approved by the
European Medicines Agency (EMA), the Food and Drug Administration (FDA) and Health …