Efficacy and safety of eslicarbazepine acetate monotherapy for partial-onset seizures: experience from a multicenter, observational study

R Toledano, CE Jovel, A Jiménez-Huete, PG Bayarri… - Epilepsy & Behavior, 2017 - Elsevier
Abstract Eslicarbazepine acetate (ESL, Aptiom™) is a once-daily anticonvulsant, approved
as adjunctive treatment of partial-onset seizures (POS). Historical-controlled trials …

Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence: experience from multicentre, double-blind, randomised …

H Grunze, E Kotlik, R Costa, T Nunes, A Falcão… - Journal of Affective …, 2015 - Elsevier
Background Eslicarbazepine acetate (ESL) is an anticonvulsant approved as an adjunctive
therapy in adults with partial-onset seizures. Objective To evaluate the efficacy, safety and …

Eslicarbazepine acetate in epilepsies with focal and secondary generalised seizures: systematic review of current evidence

LM Willems, JP Zöllner, E Paule… - Expert review of …, 2018 - Taylor & Francis
Introduction: Eslicarbazepine acetate (ESL) is a third-generation antiepileptic drug (AED)
approved for adjunctive treatment in adults, children, and adolescents with focal-onset …

Carbamazepine and oxcarbazepine, but not eslicarbazepine, enhance excitatory synaptic transmission onto hippocampal CA1 pyramidal cells through an antagonist …

SA Booker, N Pires, S Cobb, P Soares-da-Silva… - …, 2015 - Elsevier
This study assessed the anticonvulsant and seizure generation effects of carbamazepine
(CBZ), oxcarbazepine (OXC) and eslicarbazepine (S-Lic) in wild-type mice …

Eslicarbazepine acetate: a review of its use as adjunctive therapy in refractory partial-onset seizures

GM Keating - CNS drugs, 2014 - Springer
Abstract Eslicarbazepine acetate (Aptiom®, Zebinix®) is approved for the adjunctive
treatment of partial-onset seizures in adults aged≥ 18 years. Adjunctive therapy with oral …

Biologically active metabolites in drug discovery

S Sun, SS Wesolowski - Bioorganic & Medicinal Chemistry Letters, 2021 - Elsevier
Biologically active metabolites are a valuable resource for development of drug candidates
and lead structures for drug design. This digest highlights a selection of biologically active …

[HTML][HTML] Acetato de eslicarbazepina en dolor neuropático, cefaleas y neuralgias craneales: Evidencia y experiencia

AA Montero, CIS Carnerero - Neurología, 2019 - Elsevier
Introduction Eslicarbazepine acetate (ESL), together with carbamazepine and
oxcarbazepine, belongs to the dibenzazepine family. According to the latest clinical practice …

Potential efficacy and safety of eslicarbazepine acetate oral loading in patients with epilepsy

DW Kwack, DW Kim - Epilepsia, 2023 - Wiley Online Library
Eslicarbazepine acetate (ESL) is a new antiseizure medication (ASM) approved as an
adjunctive therapy or monotherapy for focal onset seizures. We performed this study to …

Population Pharmacokinetic Evaluation and Missed‐Dose Simulations for Eslicarbazepine Acetate Monotherapy in Patients With Partial‐Onset Seizures

S Sunkaraneni, D Blum, E Ludwig… - … in drug development, 2018 - Wiley Online Library
Given the potential consequences of antiepileptic therapy nonadherence, missed‐dose
scenarios of 12‐to 48‐hour dose delays (4‐hour intervals) for eslicarbazepine acetate …

Eslicarbazepine acetate as adjunctive treatment in partial‐onset epilepsy

S Lattanzi, C Cagnetti, N Foschi… - Acta Neurologica …, 2018 - Wiley Online Library
Objective The aim of the study was to assess the clinical response to eslicarbazepine
acetate (ESL) as add‐on therapy in adult patients with partial‐onset epilepsy by means of …