Most of the biological understanding of mechanisms underlying coronary artery disease
(CAD) derives from studies of mouse models. The identification of multiple CAD loci and …

Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …

The decline of endothelial autophagy is closely related to vascular senescence and disease,
although the molecular mechanisms connecting these outcomes in vascular endothelial …

Atherosclerosis is associated with inflammation in the arteries, which is a major cause of
heart attacks and strokes. Reducing the extent of local inflammation at atherosclerotic …

CD44 is a multifunctional cell receptor that conveys a cancer phenotype, regulates
macrophage inflammatory gene expression and vascular gene activation in proatherogenic …

Cardiovascular disease (CVD) due to atherosclerosis is a disease of chronic inflammation at
both the systemic and the tissue level. CD44 has previously been implicated in …

Abstract Cell-Penetrating Peptides (CPP) are valuable tools capable of crossing the plasma
membrane to deliver therapeutic cargo inside cells. Small interfering RNAs (siRNA) are …

Objective—Arteriovenous fistulae (AVF) remain the optimal conduit for hemodialysis access
but continue to demonstrate poor patency and poor rates of maturation. We hypothesized …

Cellular function and adaptive behavior is often driven by signals generated in response to
the local tissue microenvironment. Cell surface receptors that detect changes in extracellular …

The intracellular signaling events by which NADPH oxidase-generated reactive oxygen
species (ROS) modulate vascular smooth muscle cell (VSMC) function and atherogenesis …