Insulin resistance of glucose transport and metabolism in insulin-sensitive tissues is a
primary defect leading to the development of type 2 diabetes. While the etiology of insulin …

Mitochondrial dysfunction has been associated with insulin resistance, obesity and diabetes.
Hyperinsulinaemia and hyperlipidaemia are hallmarks of the insulin-resistant state. We …

Angiogenesis is an energy-demanding process; however, the role of cellular energy
pathways and their regulation by extracellular stimuli, especially extracellular nucleotides …

Dysregulation of glucose metabolism is a primary hallmark of metabolic disease (ie,
diabetes, obesity, etc.). Complementary nonpharmaceutical strategies are needed to …

Background Inhibitors of the phosphatidylinositol 3-kinase (PI3K) and the mammalian target
of rapamycin (mTOR) pathway are currently in clinical trials. In addition to antiproliferative …

Mitochondria are essential for several biological processes including energy metabolism
and cell survival. Accordingly, impaired mitochondrial function is involved in a wide range of …

Progressive research in the past decade converges to the impact of PHLPP in regulating the
cellular metabolism through PI3K/AKT inhibition. Aberrations in PKB/AKT signaling …

We recently reported translocation and activation of Akt in cardiac mitochondria. This study
was to determine whether activation of Akt in mitochondria could inhibit apoptosis of cardiac …

Insulin can translocate Akt to mitochondria in cardiac muscle. The goals of this study were to
define sub-mitochondrial localization of the translocated Akt, to dissect the effects of insulin …

The accumulation of misfolded and aggregated proteins is a hallmark of neurodegenerative
proteinopathies. Although multiple genetic loci have been associated with specific …