The effect of foetal bovine serum supplementation upon the lactate dehydrogenase cytotoxicity assay: Important considerations for in vitro toxicity analysis

MG Thomas, RM Marwood, AE Parsons, RB Parsons - Toxicology in vitro, 2015 - Elsevier
The lactate dehydrogenase (LDH) assay is a commonly-used tool for assessing toxicity in
vitro. However, anecdotal reports suggest that foetal bovine serum (FBS) may contain LDH …

[HTML][HTML] Galanthamine decreases genotoxicity and cell death induced by β-amyloid peptide in SH-SY5Y cell line

WO Castillo, AF Aristizabal-Pachon… - Neurotoxicology, 2016 - Elsevier
Biochemically, Alzheimeŕs disease (AD) is characterized by the presence of abnormal
deposition of beta amyloid peptide (Aβ (1-42)), which is generated by proteolytic processing …

Ligand-functionalized nanoliposomes for targeted delivery of galantamine

MS Mufamadi, YE Choonara, P Kumar, G Modi… - International journal of …, 2013 - Elsevier
The purpose of this study was to design ligand-functionalized nanoliposomes that are
proficient in providing effective intracellular delivery of an alkaloid drug (galantamine) into …

Bioinspired synthetic polymers-based inhibitors of Alzheimer's amyloid-β peptide aggregation

B Joseph, S Thomas, N Sen, A Paschold… - Polymer …, 2023 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease with no current cure
and limited treatment solutions, wherefore discovering of novel therapies remains a global …

Nasal application of the galantamine pro-drug memogain slows down plaque deposition and ameliorates behavior in 5X familial Alzheimer's disease mice

S Bhattacharya, A Maelicke… - Journal of Alzheimer's …, 2015 - content.iospress.com
The plant alkaloid galantamine is an established symptomatic drug treatment for Alzheimer's
disease (AD), providing cognitive and global relief in human patients. However, as an …

Use of galantamine in the treatment of Alzheimer's disease and strategies to optimize its biosynthesis using the in vitro culture technique

GS Santos, SBP Sinoti, FTC de Almeida… - Plant Cell, Tissue and …, 2020 - Springer
Galantamine is an alkaloid in the Amaryllidaceae family widely used in the treatment of
Alzheimer's disease. Since its approval for clinical use in 2001, its effectiveness has been …

Analysis of metabolic variation and galanthamine content in Narcissus bulbs by 1H NMR

A Lubbe, B Pomahačová, YH Choi… - … International Journal of …, 2010 - Wiley Online Library
Introduction–Galanthamine is a benzazepine alkaloid used as a drug to relieve symptoms of
Alzheimer's disease. For pharmaceutical use this natural product has been extracted from …

Exploring the molecular interactions of Galantamine with human Transferrin: In-silico and in vitro insight

MS Khan, FM Husain, FA Alhumaydhi… - Journal of Molecular …, 2021 - Elsevier
The iron transporter protein, Transferrin (Tf), is a glycoprotein that binds and mediates the
Iron (Fe) transport through blood plasma. It has a significant role in transporting Fe in the …

[HTML][HTML] Retrospect and prospect of active principles from Chinese herbs in the treatment of dementia

Y Wang, L Huang, X Tang, H Zhang - Acta Pharmacologica Sinica, 2010 - nature.com
With an ageing population, dementia has become one of the world's primary health
challenges. However, existing remedies offer limited benefits with certain side effects, which …

Galantamine nanoparticles outperform oral galantamine in an Alzheimer's rat model: pharmacokinetics and pharmacodynamics

SO El-Ganainy, MA Gowayed, M Agami… - …, 2021 - Taylor & Francis
Aim: Galantamine is an acetylcholinesterase inhibitor frequently used in Alzheimer's disease
management. Its cholinergic adverse effects and rapid elimination limit its therapeutic …