Effects of new galantamine derivatives in a scopolamine model of dementia in mice

M Lazarova, L Tancheva… - Journal of …, 2021 - content.iospress.com
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized
by memory loss and cognitive functions decline, is a leading cause for dementia and …

Development of retro-inverso peptides as anti-aggregation drugs for β-amyloid in Alzheimer's disease

B Matharu, O El-Agnaf, A Razvi, BM Austen - Peptides, 2010 - Elsevier
Alzheimer's disease (AD) is a devastating degenerative disorder of the brain for which there
is no cure or effective treatment. There is much evidence to suggest that β-amyloid protein …

[HTML][HTML] Alkaloids from Hippeastrum papilio

JP de Andrade, S Berkov, F Viladomat, C Codina… - Molecules, 2011 - mdpi.com
Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt
(Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from …

Inhibition of Amyloid β Aggregation and Cytotoxicity by Berbamine Hydrochloride

L Dong, HZ Xie, L Jia, L Hong… - Chemistry–A European …, 2023 - Wiley Online Library
Alzheimer's disease (AD) continues to be a major global health challenge, and the recent
approval of Aduhelm and Leqembi has opened new avenues for its treatment. Small …

Neuroprotective effects of apocynin and galantamine during the chronic administration of scopolamine in an Alzheimer's disease model

E Joseph, DMÁ Villalobos-Acosta… - Journal of Molecular …, 2020 - Springer
Alzheimer's disease (AD) is one of the most complicated neurodegenerative diseases, and
several hypotheses have been associated with its development and progression, such as …

A new naphthalene derivative with anti-amyloidogenic activity as potential therapeutic agent for Alzheimer's disease

S Rivera-Marrero, A Bencomo-Martínez… - Bioorganic & Medicinal …, 2020 - Elsevier
The aggregation of β-amyloid peptides is associated to neurodegeneration in Alzheimer's
disease (AD) patients. Consequently, the inhibition of both oligomerization and fibrillation of …

Physicochemical strategies for inhibition of amyloid fibril formation: an overview of recent advances

R Liu, R Su, M Liang, R Huang… - Current medicinal …, 2012 - ingentaconnect.com
Protein aggregation and amyloid fibrillation can lead to several serious human diseases and
protein drug ineffectiveness. The complexity and dynamics of protein folding present unique …

Cognitive enhancers (nootropics). Part 3: drugs interacting with targets other than receptors or enzymes. disease-modifying drugs

W Froestl, A Pfeifer, A Muhs - Journal of Alzheimer's Disease, 2013 - content.iospress.com
Cognitive enhancers (nootropics) are drugs to treat cognition deficits in patients suffering
from Alzheimer's disease, schizophrenia, stroke, attention deficit hyperactivity disorder, or …

Fucosterol from Sargassum horridum as an amyloid-beta (Aβ1-42) aggregation inhibitor: in vitro and in silico studies

ES Castro-Silva, M Bello… - Journal of …, 2021 - Taylor & Francis
The number of patients diagnosed with Alzheimer's disease (AD) increases each year, and
there are currently few treatment strategies to decrease the symptoms of AD; furthermore …

Structural optimization and biological evaluation of substituted bisphenol a derivatives as β-amyloid peptide aggregation inhibitors

Y Zhou, C Jiang, Y Zhang, Z Liang, W Liu… - Journal of medicinal …, 2010 - ACS Publications
The aggregation of Aβ is a crucial step in the etiology of Alzheimer's disease. Our previous
work showed that Aβ undergoes α-helix/β-sheet intermediate structures during the …