Fluorochrome-conjugated peptide–MHC (pMHC) multimers are commonly used in
combination with flow cytometry for direct ex vivo visualization and characterization of Ag …

Diffuse midline glioma is the leading cause of solid cancer-related deaths in children with
very limited treatment options. A majority of the tumors carry a point mutation in the histone 3 …

A novel coronavirus, severe acute respiratory syndrome (SARS)–associated coronavirus
(SARS-CoV), has been identified as the causal agent of SARS. Spike (S) protein is a major …

In the year 2003 there was a 17% increase in the number of publications citing work
performed using optical biosensor technology compared with the previous year. We collated …

Direct identification as well as isolation of antigen-specific T cells became possible since the
development of “tetramers” based on avidin–fluorochrome conjugates associated with mono …

The CD8 coreceptor on T cells has two functions. Namely, CD8 acts to stabilize the binding
of the T-cell receptor (TCR) to the peptide-MHC complex while localizing p56lck (lck) to the …

HLA‐sensitized patients on the transplant waiting list harbor antibodies and memory B cells
directed against allogeneic HLA molecules, which decreases the chance to receive a …

The cornerstone of the concept of immunosurveillance in cancer should be the experimental
demonstration of immune responses able to alter the course of in vivo spontaneous tumor …

Virus-based tumour vaccines offer many advantages compared to other antigen-delivering
systems. They generate concerted innate and adaptive immune response, and robust CD8+ …

Delivery of tumor-associated Ag-derived peptides in a high immunogenic form represents
one of the key issues for effective peptide-based cancer vaccine development. We report …