Many tumor antigens have been identified that can be targeted by the immune system.
Animal models that have been genetically modified to express human HLA molecules …

The tools and techniques for the study of porcine T-cells lag behind what is currently
attainable in human T-cells, so this thesis was initially focused on improvements in this field …

2. PLEASE CHECK THESE CHANGES CAREFULLY AND FAX OR E-MAIL ANY
NECESSARY CORRECTIONS TO MARIE VOLTAGGIO AT THE E-MAIL ADDRESS OR FAX …

The development of an effective human immunodeficiency virus type 1 (HIV-1) vaccine is the
best solution to the global HIV-1 pandemic. This has proven difficult due to the high mutation …

Human antigen-specific CD4+ T cells can be detected through the dual expression of
CD134 (OX40) and CD25 after 44 hours stimulation with cognate antigen. Work in this thesis …

With the continued need for drug discovery and the quest to understand disease and
treatment, there remains a requirement for improved methods to study protein-protein …

HLA-A2-restricted CTL responses to immunodominant HIV-1 epitopes do not appear to be
very effective in the control of viral replication in vivo. In this study, we studied human CD8+ …

Although several cancer immunotherapy strategies are based on the use of analog peptides
and on the modulation of the TCR affinity of adoptively transferred T cells, it remains unclear …

CD8+ CTLs are essential for effective immune defense against intracellular microbes and
neoplasia. CTLs recognize short peptide fragments presented in association with MHC class …

The impact of MHC phenotype on the shaping of the peripheral naive T cell repertoire in
humans remains unknown. To address this, we compared the frequency and antigenic …