Identification of the molecular mechanism of insulin-like growth factor-1 (IGF-1): a promising therapeutic target for neurodegenerative diseases associated with …

A Arjunan, DK Sah, M Woo, J Song - Cell & Bioscience, 2023 - Springer
Neurodegenerative disorders are accompanied by neuronal degeneration and glial
dysfunction, resulting in cognitive, psychomotor, and behavioral impairment. Multiple factors …

The impact of intermittent hypoxia on metabolism and cognition

R Shobatake, H Ota, N Takahashi, S Ueno… - International Journal of …, 2022 - mdpi.com
Intermittent hypoxia (IH), one of the primary pathologies of sleep apnea syndrome (SAS),
exposes cells throughout the body to repeated cycles of hypoxia/normoxia that result in …

[HTML][HTML] Population attributable fraction of hypertension for dementia: global, regional, and national estimates for 186 countries

MD Mulligan, R Murphy, C Reddin, C Judge… - …, 2023 - thelancet.com
Background Quantifying the proportion of dementia attributable to highly prevalent
modifiable risk factors, such as hypertension, is important in informing effective dementia …

Validation of the German Montreal-Cognitive-Assessment-H for hearing-impaired

C Völter, H Fricke, S Faour, G Lueg… - Frontiers in Aging …, 2023 - frontiersin.org
Background Hearing loss and dementia are highly prevalent in older age and often co-
occur. Most neurocognitive screening tests are auditory-based, and performance can be …

Effects of Melissa officinalis extract containing rosmarinic acid on cognition in older adults without dementia: A randomized controlled trial

M Noguchi-Shinohara, T Hamaguchi… - Journal of …, 2023 - content.iospress.com
Background: Previous in vitro and in vivo studies on Alzheimer's disease (AD) models have
reported that rosmarinic acid (RA) can inhibit the formation of amyloid-ß fibrils as well as the …

Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease

X Fang, C Tang, H Zhang, JJ Border, Y Liu, SM Shin… - Geroscience, 2023 - Springer
Alzheimer's disease (AD) is a global healthcare crisis. The TgF344-AD rat is an AD model
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …

Risk of Dementia during antihypertensive drug therapy in the elderly

F Rea, G Corrao, G Mancia - Journal of the American College of …, 2024 - jacc.org
Background Evidence exists that lowering high blood pressure reduces the risk of dementia.
However, the generalizability of this evidence to old patients from the general population …

Longitudinal trajectories of memory among middle-aged and older people with hearing loss: the influence of cochlear implant use on cognitive functioning

C Völter, L Götze, S Dazert, JP Thomas… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Cochlear implants (CI) are the gold standard intervention for severe to profound
hearing loss, a known modifiable risk factor for dementia. However, it remains unknown …

Association between Dietary Patterns and Cognitive Function among Qatari Adults: A Cross-Sectional Analysis of the Qatar Biobank Study

S Fituri, Z Shi - Nutrients, 2023 - mdpi.com
This study aimed to assess the association between dietary patterns and cognitive function
among Qatari adults. In a cross-sectional analysis, data on 1000 Qatari adults attending the …

Cognitive impairment in patients with heart failure: Molecular mechanism and therapy

Y Wu, L Chen, F Zhong, K Zhou, C Lu, X Cheng… - Heart Failure …, 2023 - Springer
Heart failure (HF) is associated with multiple organ dysfunction and many comorbidities. Its
incidence is high among the elderly and is a major health burden worldwide. Cognitive …