Osteogenesis imperfecta is a genetic disorder of increased bone fragility, low bone mass,
and other connective-tissue manifestations. The most frequently used classification outlines …

The last 2 decades have seen growing recognition of the need to appropriately identify and
treat children with osteoporotic fractures. This focus stems from important advances in our …

Publisher Summary Osteogenesis imperfecta (OI) or “brittle bone disease” is characterized
by reduced skeletal mass and bone fragility. OI has served as the paradigm for heritable …

Introduction: This study aimed to establish sex-and age-specific reference curves enabling
the calculation of z-scores and to examine correlations between bone markers and …

This article reviews the manifestations and risk factors associated with osteoporosis in
childhood, the definition of osteoporosis and recommendations for monitoring and …

Glucocorticoids (GC) are an important risk factor for bone fragility in children with serious
illnesses, largely due to their direct adverse effects on skeletal metabolism. To better …

Osteogenesis Imperfecta (OI) is a rare heritable condition characterized by bone fragility and
reduced bone mass. Traditionally OI was classified into OI types I to IV and thought to be …

Abstract Background Osteogenesis Imperfecta (OI) is a disease with varying severity
affecting physical, social and emotional well-being of the child and their family. There is no …

Osteogenesis imperfecta (OI) is a heterogeneous group of disorders of connective tissue,
caused mainly by mutations in the collagen I genes (COL1A1 and COL1A2) …

Clinical and histomorphometric outcome was compared between children with OI who had
received pamidronate since infancy and age‐matched patients who had never received …