Mechanisms and treatment of late-life depression

GS Alexopoulos - Translational psychiatry, 2019 - nature.com
Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

[HTML][HTML] TMS combined with EEG: Recommendations and open issues for data collection and analysis

JC Hernandez-Pavon, D Veniero, TO Bergmann… - Brain Stimulation, 2023 - Elsevier
Transcranial magnetic stimulation (TMS) evokes neuronal activity in the targeted cortex and
connected brain regions. The evoked brain response can be measured with …

Oligodendrocyte lineage cells and depression

B Zhou, Z Zhu, BR Ransom, X Tong - Molecular psychiatry, 2021 - nature.com
Depression is a common mental illness, affecting more than 300 million people worldwide.
Decades of investigation have yielded symptomatic therapies for this disabling condition but …

Depression, neuroimaging and connectomics: a selective overview

Q Gong, Y He - Biological psychiatry, 2015 - Elsevier
Depression is a multifactorial disorder with clinically heterogeneous features involving
disturbances of mood and cognitive function. Noninvasive neuroimaging studies have …

Frontocingulate dysfunction in depression: toward biomarkers of treatment response

DA Pizzagalli - Neuropsychopharmacology, 2011 - nature.com
Increased rostral anterior cingulate cortex (rACC) activity has emerged as a promising
predictor of treatment response in depression, but neither the reliability of this relationship …

The basolateral amygdala-anterior cingulate pathway contributes to depression-like behaviors and comorbidity with chronic pain behaviors in male mice

LJ Becker, C Fillinger, R Waegaert, SH Journée… - Nature …, 2023 - nature.com
While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Brain volume abnormalities in major depressive disorder: A meta‐analysis of magnetic resonance imaging studies

PCMP Koolschijn, NEM van Haren… - Human brain …, 2009 - Wiley Online Library
Objective. So far, there have been no attempts to integrate the growing number of all brain
volumetric magnetic resonance imaging studies in depression. In this comprehensive meta …

Obstructive sleep apnea is linked to depression and cognitive impairment: evidence and potential mechanisms

NA Kerner, SP Roose - The American Journal of Geriatric Psychiatry, 2016 - Elsevier
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is
an independent risk factor for depression and cognitive impairment/dementia. Herein the …

Functional connectivity in the cognitive control network and the default mode network in late-life depression

GS Alexopoulos, MJ Hoptman, D Kanellopoulos… - Journal of affective …, 2012 - Elsevier
BACKGROUND: Abnormalities have been identified in the Cognitive Control Network (CCN)
and the Default Mode Network (DMN) during episodes of late-life depression. This study …

Treating bipolar depression with esketamine: Safety and effectiveness data from a naturalistic multicentric study on esketamine in bipolar versus unipolar treatment …

G Martinotti, B Dell'Osso, G Di Lorenzo… - Bipolar …, 2023 - Wiley Online Library
Background Bipolar depression accounts for most of the disease duration in type I and type
II bipolar disorder (BD), with few treatment options, often poorly tolerated. Many individuals …