Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

Fibronectin structure and composition regulate contextual cell signaling. Recent advances
have been made in understanding fibronectin and its role in tissue organization and repair …

Extracellular matrix (ECM) is the foundation on which all cells and organs converge to
orchestrate normal physiological functions. In the setting of pathology, the ECM is modified …

Pancreatic cancer is typically detected at an advanced stage, and is refractory to most forms
of treatment, contributing to poor survival outcomes. The incidence of pancreatic cancer is …

The identification of contributing factors leading to the development of Colorectal Cancer
(CRC), as the third fatal malignancy, is crucial. Today, the tumor microenvironment has been …

Background Tumor heterogeneity plays essential roles in developing cancer therapies,
including therapies for breast cancer (BC). In addition, it is also very important to understand …

Background: Cancer-associated fibroblasts (CAFs) are of considerable importance in tumor
progression by interacting with the tumor microenvironment. However, the hidden …

Tumor development and progression hinge upon ongoing coevolution and crosstalk with the
tumor microenvironment. In particular, fibroblasts in the tumor stroma are coopted to support …

Desmoplasia in breast cancer leads to heterogeneity in physical properties of the tissue,
resulting in disparities in drug delivery and treatment efficacy among patients, thus …

Cellular secretions are a fundamental aspect of cell–cell and cell–matrix interactions in vivo.
In malignancy, cancer cells have an aberrant secretome compared to their non-malignant …