A clinical update and global economic burden of rheumatoid arthritis
Background and Objective: Rheumatoid arthritis (RA) is a predominant inflammatory
autoimmune disorder. The incidence and prevalence of RA is increasing with considerable …
autoimmune disorder. The incidence and prevalence of RA is increasing with considerable …
SLC19A1 transports immunoreactive cyclic dinucleotides
RD Luteijn, SA Zaver, BG Gowen, SK Wyman… - Nature, 2019 - nature.com
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal
associated with infections, cancer and genomic damage,. Cytosolic DNA triggers immune …
associated with infections, cancer and genomic damage,. Cytosolic DNA triggers immune …
Nanomedicine Strategies for Anti‐Inflammatory Treatment of Noninfectious Arthritis
L Chen, Y Wang, L Sun, J Yan… - Advanced Healthcare …, 2021 - Wiley Online Library
Noninfectious arthritis (NIA) comprises a class of chronic and progressive inflammatory
disorders that require early‐stage management to prevent disease progression. The most …
disorders that require early‐stage management to prevent disease progression. The most …
Polymer nanotherapeutics to correct autoimmunity
T Su, X Feng, J Yang, W Xu, T Liu, M Zhang… - Journal of Controlled …, 2022 - Elsevier
The immune system maintains homeostasis and protects the body from pathogens, mutated
cells, and other harmful substances. When immune homeostasis is disrupted, excessive …
cells, and other harmful substances. When immune homeostasis is disrupted, excessive …
Development of methotrexate loaded fucoidan/chitosan nanoparticles with anti-inflammatory potential and enhanced skin permeation
In this study, fucoidan/chitosan nanoparticles were developed for the topical delivery of
methotrexate towards the treatment of skin-related inflammatory diseases. Based on the …
methotrexate towards the treatment of skin-related inflammatory diseases. Based on the …
Development of a novel methotrexate-loaded nanoemulsion for rheumatoid arthritis treatment with site-specific targeting subcutaneous delivery
P Suresh, MM Salem-Bekhit, HP Veedu, S Alshehri… - Nanomaterials, 2022 - mdpi.com
Rheumatoid arthritis (RA) is a systemic, chronic autoimmune disease that causes disability
due to progressive inflammation and destruction of the tissues around the joints …
due to progressive inflammation and destruction of the tissues around the joints …
Rebamipide potentially mitigates methotrexate‐induced nephrotoxicity via inhibition of oxidative stress and inflammation: A molecular and histochemical study
Methotrexate (MTX) is a widely used chemotherapeutic agent; nevertheless, the
nephrotoxicity associated with its use has limited its clinical use. Rebamipide (REB) is a …
nephrotoxicity associated with its use has limited its clinical use. Rebamipide (REB) is a …
The Essential Oil Derived from Perilla frutescens (L.) Britt. Attenuates Imiquimod–Induced Psoriasis-like Skin Lesions in BALB/c Mice
Y Xu, Y Shi, J Huang, H Gu, C Li, L Zhang, G Liu… - Molecules, 2022 - mdpi.com
Psoriasis is reported to be a common chronic immune-mediated skin disease characterized
by abnormal keratinocytes and cell proliferation. Perilla leaves are rich in essential oils, fatty …
by abnormal keratinocytes and cell proliferation. Perilla leaves are rich in essential oils, fatty …
Protective effects of magnesium glycyrrhizinate on methotrexate-induced hepatotoxicity and intestinal toxicity may be by reducing COX-2
Y Cao, H Shi, Z Sun, J Wu, Y Xia, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Magnesium isoglycyrrhizinate (MgIG), which has been widely employed to treat chronic
hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese …
hepatitis, is synthesized from 18-β glycyrrhizic acid, a main component of traditional Chinese …
Protocatechuic acid inhibits testicular and epididymal toxicity associated with methotrexate in rats
SE Owumi, SE Ochaoga, OA Odunola… - Andrologia, 2019 - Wiley Online Library
We examined the effect of protocatechuic acid (PCA) on methotrexate (MTX)‐induced
testicular and epididymal toxicity in Wistar rats, treated with MTX (20 mg/kg) alone or in …
testicular and epididymal toxicity in Wistar rats, treated with MTX (20 mg/kg) alone or in …